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Article: Chemical composition of gallbladder sludge in patients after marrow transplantation

TitleChemical composition of gallbladder sludge in patients after marrow transplantation
Authors
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1996, v. 91 n. 6, p. 1207-1210 How to Cite?
AbstractObjectives: Gallbladder sludge develops in approximately 70% of patients after bone marrow transplantation (BMT). Sludge often develops in these patients without known predisposing factors, such as fasting or narcotic use. In this study, we examined the chemical composition of sludge in BMT patients. Methods: Gallbladder content samples from 15 patients were obtained at autopsy. Presence or absence of sludge was determined by examination of gallbladder contents. Sludge samples were examined with direct and polarizing microscopy and assayed for cholesterol, bilirubin, and calcium content and for the presence of a calcium-binding protein. Results: On microscopic examination, cholesterol monohydrate crystals were almost completely absent. Calcium bilirubinate crystals were present in large amounts in all samples. Calcium-ceftriaxone crystals were found in two patients who had received ceftriaxone. A large proportion of the sludge (84.6%) was found to be 'unmeasurable residue.' Of this part, 5-30% was accounted for by a calcium- binding protein. Conclusions: We conclude that gallbladder sludge in patients after marrow transplantation consists primarily of 'unmeasurable residue,' calcium bilirubinate, and a calcium-binding protein. Cholesterol crystals are almost absent. We conclude that formation of gallbladder sludge in these patients could serve as a model for studying the pathogenesis of pigment gallstones.
Persistent Identifierhttp://hdl.handle.net/10722/175753
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKo, CWen_US
dc.contributor.authorMurakami, Cen_US
dc.contributor.authorSekijima, JHen_US
dc.contributor.authorKim, MHen_US
dc.contributor.authorMcdonald, GBen_US
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:01:00Z-
dc.date.available2012-11-26T09:01:00Z-
dc.date.issued1996en_US
dc.identifier.citationAmerican Journal Of Gastroenterology, 1996, v. 91 n. 6, p. 1207-1210en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/175753-
dc.description.abstractObjectives: Gallbladder sludge develops in approximately 70% of patients after bone marrow transplantation (BMT). Sludge often develops in these patients without known predisposing factors, such as fasting or narcotic use. In this study, we examined the chemical composition of sludge in BMT patients. Methods: Gallbladder content samples from 15 patients were obtained at autopsy. Presence or absence of sludge was determined by examination of gallbladder contents. Sludge samples were examined with direct and polarizing microscopy and assayed for cholesterol, bilirubin, and calcium content and for the presence of a calcium-binding protein. Results: On microscopic examination, cholesterol monohydrate crystals were almost completely absent. Calcium bilirubinate crystals were present in large amounts in all samples. Calcium-ceftriaxone crystals were found in two patients who had received ceftriaxone. A large proportion of the sludge (84.6%) was found to be 'unmeasurable residue.' Of this part, 5-30% was accounted for by a calcium- binding protein. Conclusions: We conclude that gallbladder sludge in patients after marrow transplantation consists primarily of 'unmeasurable residue,' calcium bilirubinate, and a calcium-binding protein. Cholesterol crystals are almost absent. We conclude that formation of gallbladder sludge in these patients could serve as a model for studying the pathogenesis of pigment gallstones.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.subject.meshAutopsyen_US
dc.subject.meshBile - Chemistryen_US
dc.subject.meshBilirubin - Analysisen_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshCalcium - Analysisen_US
dc.subject.meshCalcium-Binding Proteins - Analysisen_US
dc.subject.meshCholelithiasis - Chemistry - Etiologyen_US
dc.subject.meshCholesterol - Analysisen_US
dc.subject.meshCrystallizationen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroscopy, Polarizationen_US
dc.titleChemical composition of gallbladder sludge in patients after marrow transplantationen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8651172-
dc.identifier.scopuseid_2-s2.0-0030004139en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030004139&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume91en_US
dc.identifier.issue6en_US
dc.identifier.spage1207en_US
dc.identifier.epage1210en_US
dc.identifier.isiWOS:A1996UP42000025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKo, CW=7202596492en_US
dc.identifier.scopusauthoridMurakami, C=7004774632en_US
dc.identifier.scopusauthoridSekijima, JH=6506103215en_US
dc.identifier.scopusauthoridKim, MH=38260921400en_US
dc.identifier.scopusauthoridMcDonald, GB=7203029062en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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