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Article: Does familiality predispose to both emergence and persistence of psychosis? A follow-up study

TitleDoes familiality predispose to both emergence and persistence of psychosis? A follow-up study
Authors
Issue Date1996
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1996, v. 168 MAY, p. 620-626 How to Cite?
AbstractBackground. It has been suggested that in schizophrenia an association exists between family history of schizophrenia and poor outcome on the one hand, and family history of affective disorders and good outcome on the other. Method. We tested for associations between four-year outcome and familiar loading for psychotic disorders in a mixed sample of 150 consecutively admitted patients with functional psychosis (schizophrenia, psychotic affective disorders, other psychotic disorders) of recent onset. For each proband, a familial loading score for (i) broadly defined psychotic disorder, (ii) schizophrenia, and (iii) affective disorder was calculated using information on relatives obtained through the Family History Research Diagnostic Criteria method and direct interviews of relatives with the Schedule for Affective Disorders and Schizophrenia. Results. In our sample of psychotic patients, familiar loading for psychotic disorder predicted persistent negative symptoms over the follow-up period (OR 1.5; 95% CI 1-2.2), especially in schizophrenia, and was also associated with more time hospitalised (P > 0.05), and more social disability at follow-up (P < 0.05). Greater familial loading for schizophrenia predicted a greater likelihood of non-recovery (OR 2.2; 95% CI 1.1-4.4) and a greater likelihood to have had persistent negative symptoms over the follow-up period (OR 1.7; 95% CI 0.9-3.1). No association was found between outcome and familial loading for affective disorder. Conclusions. We conclude that familial loading may be a continuous risk factor for some dimensions of clinical outcome in the functional psychoses. This suggests that there is a continuum of genetic liability not only to the emergence of psychotic illness, but also the subsequent chronicity of the disorder.
Persistent Identifierhttp://hdl.handle.net/10722/175752
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVerdoux, Hen_US
dc.contributor.authorVan Os, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorJones, Pen_US
dc.contributor.authorGilvarry, Ken_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:00:59Z-
dc.date.available2012-11-26T09:00:59Z-
dc.date.issued1996en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1996, v. 168 MAY, p. 620-626en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175752-
dc.description.abstractBackground. It has been suggested that in schizophrenia an association exists between family history of schizophrenia and poor outcome on the one hand, and family history of affective disorders and good outcome on the other. Method. We tested for associations between four-year outcome and familiar loading for psychotic disorders in a mixed sample of 150 consecutively admitted patients with functional psychosis (schizophrenia, psychotic affective disorders, other psychotic disorders) of recent onset. For each proband, a familial loading score for (i) broadly defined psychotic disorder, (ii) schizophrenia, and (iii) affective disorder was calculated using information on relatives obtained through the Family History Research Diagnostic Criteria method and direct interviews of relatives with the Schedule for Affective Disorders and Schizophrenia. Results. In our sample of psychotic patients, familiar loading for psychotic disorder predicted persistent negative symptoms over the follow-up period (OR 1.5; 95% CI 1-2.2), especially in schizophrenia, and was also associated with more time hospitalised (P > 0.05), and more social disability at follow-up (P < 0.05). Greater familial loading for schizophrenia predicted a greater likelihood of non-recovery (OR 2.2; 95% CI 1.1-4.4) and a greater likelihood to have had persistent negative symptoms over the follow-up period (OR 1.7; 95% CI 0.9-3.1). No association was found between outcome and familial loading for affective disorder. Conclusions. We conclude that familial loading may be a continuous risk factor for some dimensions of clinical outcome in the functional psychoses. This suggests that there is a continuum of genetic liability not only to the emergence of psychotic illness, but also the subsequent chronicity of the disorder.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBipolar Disorder - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshLength Of Stayen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshPsychotic Disorders - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSchizotypal Personality Disorder - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleDoes familiality predispose to both emergence and persistence of psychosis? A follow-up studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.168.5.620-
dc.identifier.pmid8733802-
dc.identifier.scopuseid_2-s2.0-0030003982en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030003982&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume168en_US
dc.identifier.issueMAYen_US
dc.identifier.spage620en_US
dc.identifier.epage626en_US
dc.identifier.isiWOS:A1996UJ34500015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVerdoux, H=7103223364en_US
dc.identifier.scopusauthoridVan Os, J=7102358027en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridJones, P=36078972900en_US
dc.identifier.scopusauthoridGilvarry, K=6508391739en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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