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Article: A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

TitleA combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12
Authors
Issue Date1996
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1996, v. 67 n. 1, p. 40-45 How to Cite?
AbstractSeveral groups have reported weak evidence for linkage between schizophrenia and genetic markers located on chromosome 22q using the lod score method of analysis. However these findings involved different genetic markers and methods of analysis, and so were not directly comparable. To resolve this issue we have performed a combined analysis of genotypic data from the marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. This marker was chosen because it showed maximum evidence for linkage in three independent datasets (Vallada et al., Am J Med Genet 60: 139-146, 1995; Polymeropoulos et al., Neuropsychiatr Genet 54: 93-99, 1994; Lasseter et al., Am J Med Genet, 60: 172-173, 1995. Using the affected sib-pair method as implemented by the program ESPA, the combined dataset showed 252 alleles shared compared with 188 alleles not shared (chi-square 9.31, 1df, P = 0.001) where parental genotype data was completely known. When sib-pairs for whom parental data was assigned according to probability were included the number of alleles shared was 514.1 compared with 437.8 not shared (chi-square 6.12, 1df, P = 0.006). Similar results were obtained when a likelihood ratio method for sib-pair analysis was used. These results indicate that may be a susceptibility locus for schizophrenia at 22q12.
Persistent Identifierhttp://hdl.handle.net/10722/175746
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGill, Men_US
dc.contributor.authorVallada, Hen_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorHolmans, Pen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorNanko, Sen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorAntonarakis, Sen_US
dc.contributor.authorHousman, Den_US
dc.contributor.authorKazazian, Hen_US
dc.contributor.authorNestadt, Gen_US
dc.contributor.authorPulver, AEen_US
dc.contributor.authorStraub, REen_US
dc.contributor.authorMaclean, CJen_US
dc.contributor.authorWalsh, Den_US
dc.contributor.authorKendler, KSen_US
dc.contributor.authorDelisi, Len_US
dc.date.accessioned2012-11-26T09:00:56Z-
dc.date.available2012-11-26T09:00:56Z-
dc.date.issued1996en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1996, v. 67 n. 1, p. 40-45en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175746-
dc.description.abstractSeveral groups have reported weak evidence for linkage between schizophrenia and genetic markers located on chromosome 22q using the lod score method of analysis. However these findings involved different genetic markers and methods of analysis, and so were not directly comparable. To resolve this issue we have performed a combined analysis of genotypic data from the marker D22S278 in multiply affected schizophrenic families derived from 11 independent research groups worldwide. This marker was chosen because it showed maximum evidence for linkage in three independent datasets (Vallada et al., Am J Med Genet 60: 139-146, 1995; Polymeropoulos et al., Neuropsychiatr Genet 54: 93-99, 1994; Lasseter et al., Am J Med Genet, 60: 172-173, 1995. Using the affected sib-pair method as implemented by the program ESPA, the combined dataset showed 252 alleles shared compared with 188 alleles not shared (chi-square 9.31, 1df, P = 0.001) where parental genotype data was completely known. When sib-pairs for whom parental data was assigned according to probability were included the number of alleles shared was 514.1 compared with 437.8 not shared (chi-square 6.12, 1df, P = 0.006). Similar results were obtained when a likelihood ratio method for sib-pair analysis was used. These results indicate that may be a susceptibility locus for schizophrenia at 22q12.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 22en_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshGenetic Heterogeneityen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleA combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1096-8628(19960216)67:1<40::AID-AJMG6>3.0.CO;2-Wen_US
dc.identifier.pmid8678112-
dc.identifier.scopuseid_2-s2.0-0029874880en_US
dc.identifier.volume67en_US
dc.identifier.issue1en_US
dc.identifier.spage40en_US
dc.identifier.epage45en_US
dc.identifier.isiWOS:A1996TY40300007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGill, M=14633481100en_US
dc.identifier.scopusauthoridVallada, H=7003742958en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridHolmans, P=7004028945en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridNanko, S=7006294283en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridAntonarakis, S=36049009800en_US
dc.identifier.scopusauthoridHousman, D=7102570207en_US
dc.identifier.scopusauthoridKazazian, H=7102525271en_US
dc.identifier.scopusauthoridNestadt, G=7004065426en_US
dc.identifier.scopusauthoridPulver, AE=7003671868en_US
dc.identifier.scopusauthoridStraub, RE=7203034348en_US
dc.identifier.scopusauthoridMacLean, CJ=7102972772en_US
dc.identifier.scopusauthoridWalsh, D=7402053258en_US
dc.identifier.scopusauthoridKendler, KS=35396760800en_US
dc.identifier.scopusauthoridDeLisi, L=35374352700en_US

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