File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients

TitleAnalysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients
Authors
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 6, p. 541-545 How to Cite?
AbstractWe have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48-bp repeat, which range from two to ten copies in the normal human population, were analysed by the polymerase chain reaction using genomic DNA as template. Association between these alleles and response to clozapine was tested using the difference in pre-and post-treatment GAS scores as a measure of response. We found no statistically significant variation between genotypic groups and response by analysis of variance. We conclude that the variation of the number of 48-bp repeats alone does not determine response to clozapine. Larger studies are underway to determine if there is a more subtle relationship with sequence variation within the repeats or at other polymorphic sites within the gene that may provide evidence for a component of clozapine's action being at D4 receptors.
Persistent Identifierhttp://hdl.handle.net/10722/175737
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShaikh, Sen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorPilowsky, Len_US
dc.contributor.authorSharma, Ten_US
dc.contributor.authorLin, LKen_US
dc.contributor.authorCrocq, MAen_US
dc.contributor.authorGill, Men_US
dc.contributor.authorKerwin, Ren_US
dc.date.accessioned2012-11-26T09:00:52Z-
dc.date.available2012-11-26T09:00:52Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 6, p. 541-545en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175737-
dc.description.abstractWe have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48-bp repeat, which range from two to ten copies in the normal human population, were analysed by the polymerase chain reaction using genomic DNA as template. Association between these alleles and response to clozapine was tested using the difference in pre-and post-treatment GAS scores as a measure of response. We found no statistically significant variation between genotypic groups and response by analysis of variance. We conclude that the variation of the number of 48-bp repeats alone does not determine response to clozapine. Larger studies are underway to determine if there is a more subtle relationship with sequence variation within the repeats or at other polymorphic sites within the gene that may provide evidence for a component of clozapine's action being at D4 receptors.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshClozapine - Pharmacologyen_US
dc.subject.meshDna Primersen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D4en_US
dc.subject.meshRepetitive Sequences, Nucleic Acid - Geneticsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleAnalysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patientsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600611en_US
dc.identifier.pmid8825892-
dc.identifier.scopuseid_2-s2.0-0029560535en_US
dc.identifier.volume60en_US
dc.identifier.issue6en_US
dc.identifier.spage541en_US
dc.identifier.epage545en_US
dc.identifier.isiWOS:A1995TK75100010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShaikh, S=36485513100en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridPilowsky, L=7004415480en_US
dc.identifier.scopusauthoridSharma, T=7202571892en_US
dc.identifier.scopusauthoridLin, LK=14634159900en_US
dc.identifier.scopusauthoridCrocq, MA=7003773716en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US
dc.identifier.scopusauthoridKerwin, R=7102904567en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats