File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An extended transmission/disequilibrium test (TDT) for multi-allele marker loci

TitleAn extended transmission/disequilibrium test (TDT) for multi-allele marker loci
Authors
Issue Date1995
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 1995, v. 59 n. 3, p. 323-336 How to Cite?
AbstractThe transmission/disequilibrium test (TDT) was recently introduced by Spielman et al. as a test for linkage and linkage disequilibrium. The test is based on the unequal probability of transmission of two different marker alleles from parents to affected offspring, when the marker locus and the hypothetical disease locus are linked and are in linkage disequilibrium. The probabilities of marker allele transmission to affected offspring conditional on parental genotype have been derived by Ott for a biallelic marker and a recessive disorder with no phenocopies. Here, we derive the transmission probabilities for a multi-allele marker locus and a generalized single locus disease model in a random sample of affected individuals from a randomly mating population. The form of these transmission probabilities suggests an extension of the TDT to multi-allele marker loci, in which the alternative hypothesis is restricted to take account of the likely pattern of unequal transmission when the recombination fraction is near 0. We show how our extended TDT can be implemented by standard software for logistic regression, although we have also written our own program which is available on request. We have evaluated the approximate power of the test under a range of realistic assumptions, and it appears that the test will often have good power when linkage disequilibrium is strong and if the disease is recessive.
Persistent Identifierhttp://hdl.handle.net/10722/175724
ISSN
2015 Impact Factor: 1.889
2015 SCImago Journal Rankings: 1.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorCurtis, Den_US
dc.date.accessioned2012-11-26T09:00:46Z-
dc.date.available2012-11-26T09:00:46Z-
dc.date.issued1995en_US
dc.identifier.citationAnnals Of Human Genetics, 1995, v. 59 n. 3, p. 323-336en_US
dc.identifier.issn0003-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/175724-
dc.description.abstractThe transmission/disequilibrium test (TDT) was recently introduced by Spielman et al. as a test for linkage and linkage disequilibrium. The test is based on the unequal probability of transmission of two different marker alleles from parents to affected offspring, when the marker locus and the hypothetical disease locus are linked and are in linkage disequilibrium. The probabilities of marker allele transmission to affected offspring conditional on parental genotype have been derived by Ott for a biallelic marker and a recessive disorder with no phenocopies. Here, we derive the transmission probabilities for a multi-allele marker locus and a generalized single locus disease model in a random sample of affected individuals from a randomly mating population. The form of these transmission probabilities suggests an extension of the TDT to multi-allele marker loci, in which the alternative hypothesis is restricted to take account of the likely pattern of unequal transmission when the recombination fraction is near 0. We show how our extended TDT can be implemented by standard software for logistic regression, although we have also written our own program which is available on request. We have evaluated the approximate power of the test under a range of realistic assumptions, and it appears that the test will often have good power when linkage disequilibrium is strong and if the disease is recessive.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_US
dc.relation.ispartofAnnals of Human Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.titleAn extended transmission/disequilibrium test (TDT) for multi-allele marker locien_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1469-1809.1995.tb00751.x-
dc.identifier.pmid7486838-
dc.identifier.scopuseid_2-s2.0-0028981182en_US
dc.identifier.volume59en_US
dc.identifier.issue3en_US
dc.identifier.spage323en_US
dc.identifier.epage336en_US
dc.identifier.isiWOS:A1995RM72100006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCurtis, D=14633020700en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats