File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Schizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected families

TitleSchizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected families
Authors
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 377-381 How to Cite?
AbstractCrow et al. [1993: Am J Med Genet (Neuropsychiatr Genet) 48:159-160] have reported excess sharing of alleles by male sibling pairs with schizophrenia, at a triplet repeat marker within the androgen receptor gene, indicating that mutations at or near this gene may be a risk factor for males. In this report, we describe a pair of male siblings concordant for both schizophrenia and Reifenstein syndrome, which is caused by a mutation in this gene. This provides support for the hypothesis that the androgen receptor may contribute to liability to develop schizophrenia. Because of this, we have examined a collection of 23 pedigrees multiply affected by schizophrenia for linkage to the androgen receptor. We have found no evidence for linkage by both the LOD score and affected sibling-pair methods, under a range of genetic models with a broad and narrow definition of phenotype, and when families with male-to- male transmission are excluded. However, because of the small number of informative male-male pairs in our sample, we cannot confirm or refute the excess allele sharing for males reported by Crow.
Persistent Identifierhttp://hdl.handle.net/10722/175715
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorArranz, Men_US
dc.contributor.authorSharma, Ten_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKerwin, Ren_US
dc.contributor.authorNanko, Sen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorGill, Men_US
dc.contributor.authorCollier, Den_US
dc.date.accessioned2012-11-26T09:00:42Z-
dc.date.available2012-11-26T09:00:42Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 377-381en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175715-
dc.description.abstractCrow et al. [1993: Am J Med Genet (Neuropsychiatr Genet) 48:159-160] have reported excess sharing of alleles by male sibling pairs with schizophrenia, at a triplet repeat marker within the androgen receptor gene, indicating that mutations at or near this gene may be a risk factor for males. In this report, we describe a pair of male siblings concordant for both schizophrenia and Reifenstein syndrome, which is caused by a mutation in this gene. This provides support for the hypothesis that the androgen receptor may contribute to liability to develop schizophrenia. Because of this, we have examined a collection of 23 pedigrees multiply affected by schizophrenia for linkage to the androgen receptor. We have found no evidence for linkage by both the LOD score and affected sibling-pair methods, under a range of genetic models with a broad and narrow definition of phenotype, and when families with male-to- male transmission are excluded. However, because of the small number of informative male-male pairs in our sample, we cannot confirm or refute the excess allele sharing for males reported by Crow.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshDisorders Of Sex Development - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutationen_US
dc.subject.meshPedigreeen_US
dc.subject.meshReceptors, Androgen - Geneticsen_US
dc.subject.meshSchizophrenia - Genetics - Metabolismen_US
dc.subject.meshSyndromeen_US
dc.subject.meshX Chromosomeen_US
dc.titleSchizophrenia and the androgen receptor gene: Report of a sibship showing co-segregation with Reifenstein syndrome but no evidence for linkage in 23 multiply affected familiesen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600506en_US
dc.identifier.pmid8546149-
dc.identifier.scopuseid_2-s2.0-0028864732en_US
dc.identifier.volume60en_US
dc.identifier.issue5en_US
dc.identifier.spage377en_US
dc.identifier.epage381en_US
dc.identifier.isiWOS:A1995RZ63800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridArranz, M=7006010757en_US
dc.identifier.scopusauthoridSharma, T=7202571892en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKerwin, R=7102904567en_US
dc.identifier.scopusauthoridNanko, S=7006294283en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats