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Article: An association study of a neurotrophin-3 (NT-3) gene polymorphism with schizophrenia

TitleAn association study of a neurotrophin-3 (NT-3) gene polymorphism with schizophrenia
Authors
Issue Date1995
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP
Citation
Acta Psychiatrica Scandinavica, 1995, v. 92 n. 6, p. 425-428 How to Cite?
AbstractSince abnormalities of brain development play a role in the aetiology of schizophrenia, growth factors, known to play a role in neurodevelopment, such as neurotrophin-3 (NT-3), are therefore candidate genes for this disorder. The A3/147 bp allele of a dinucleotide repeat polymorphism in the promoter region of the NT-3 gene has been reported as occurring more frequently in a sample of Japanese schizophrenics compared to controls. We have determined the frequency of alleles of this polymorphism in 175 Caucasian schizophrenic patients and 147 control subjects. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and, in a test of all alleles, the patients and controls did not differ significantly in allele frequencies. However, the male schizophrenics were more likely than male controls to have the A3/147 bp allele (P = 0.029).
Persistent Identifierhttp://hdl.handle.net/10722/175714
ISSN
2015 Impact Factor: 6.128
2015 SCImago Journal Rankings: 2.518
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDawson, Een_US
dc.contributor.authorPowell, JFen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorNothen, Men_US
dc.contributor.authorCrocq, MAen_US
dc.contributor.authorPropping, Pen_US
dc.contributor.authorKorner, Jen_US
dc.contributor.authorRietschel, Men_US
dc.contributor.authorVan Os, Jen_US
dc.contributor.authorWright, Pen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorGill, Men_US
dc.date.accessioned2012-11-26T09:00:41Z-
dc.date.available2012-11-26T09:00:41Z-
dc.date.issued1995en_US
dc.identifier.citationActa Psychiatrica Scandinavica, 1995, v. 92 n. 6, p. 425-428en_US
dc.identifier.issn0001-690Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175714-
dc.description.abstractSince abnormalities of brain development play a role in the aetiology of schizophrenia, growth factors, known to play a role in neurodevelopment, such as neurotrophin-3 (NT-3), are therefore candidate genes for this disorder. The A3/147 bp allele of a dinucleotide repeat polymorphism in the promoter region of the NT-3 gene has been reported as occurring more frequently in a sample of Japanese schizophrenics compared to controls. We have determined the frequency of alleles of this polymorphism in 175 Caucasian schizophrenic patients and 147 control subjects. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and, in a test of all alleles, the patients and controls did not differ significantly in allele frequencies. However, the male schizophrenics were more likely than male controls to have the A3/147 bp allele (P = 0.029).en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACPen_US
dc.relation.ispartofActa Psychiatrica Scandinavicaen_US
dc.subject.meshAllelesen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshEuropeen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshJapanen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleAn association study of a neurotrophin-3 (NT-3) gene polymorphism with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0447.1995.tb09607.x-
dc.identifier.pmid8837968-
dc.identifier.scopuseid_2-s2.0-0028841035en_US
dc.identifier.volume92en_US
dc.identifier.issue6en_US
dc.identifier.spage425en_US
dc.identifier.epage428en_US
dc.identifier.isiWOS:A1995TL41000004-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridDawson, E=7102147964en_US
dc.identifier.scopusauthoridPowell, JF=7403541196en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridNothen, M=35355123900en_US
dc.identifier.scopusauthoridCrocq, MA=7003773716en_US
dc.identifier.scopusauthoridPropping, P=35355673000en_US
dc.identifier.scopusauthoridKorner, J=7102394501en_US
dc.identifier.scopusauthoridRietschel, M=7006620620en_US
dc.identifier.scopusauthoridVan Os, J=7102358027en_US
dc.identifier.scopusauthoridWright, P=7404316244en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US

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