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Article: No evidence for linkage between the X-chromosome marker DXS7 and schizophrenia

TitleNo evidence for linkage between the X-chromosome marker DXS7 and schizophrenia
Authors
Issue Date1995
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 461-464 How to Cite?
AbstractDeLisi et al. (1994b) have examined the X and Y chromosomes for linkage to schizophrenia in 126 small families and report a small positive LOD score for the marker DXS7, adjacent to the MAO locus at Xp11.4-11.3. Because of this, we have examined the DXS7 for linkage to schizophrenia using 17 pedigrees in which male-to-male transmission of schizophrenia was absent. Alleles at DXS7 were genotyped using the PCR and LOD scores calculated using five models of inheritance, including classical dominant recessive and intermediate models. LOD scores were substantially negative for all models examined and analysis for linkage heterogeneity using the LOD2 method showed no significance. Analysis by the nonparametric affected sib-pair method likewise indicated no linkage. We conclude that DXS7 is not a major locus for schizophrenia in our collection of pedigrees.
Persistent Identifierhttp://hdl.handle.net/10722/175712
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOkoro, Cen_US
dc.contributor.authorBell, Ren_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorNanko, Sen_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorGill, Men_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, Den_US
dc.date.accessioned2012-11-26T09:00:40Z-
dc.date.available2012-11-26T09:00:40Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1995, v. 60 n. 5, p. 461-464en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175712-
dc.description.abstractDeLisi et al. (1994b) have examined the X and Y chromosomes for linkage to schizophrenia in 126 small families and report a small positive LOD score for the marker DXS7, adjacent to the MAO locus at Xp11.4-11.3. Because of this, we have examined the DXS7 for linkage to schizophrenia using 17 pedigrees in which male-to-male transmission of schizophrenia was absent. Alleles at DXS7 were genotyped using the PCR and LOD scores calculated using five models of inheritance, including classical dominant recessive and intermediate models. LOD scores were substantially negative for all models examined and analysis for linkage heterogeneity using the LOD2 method showed no significance. Analysis by the nonparametric affected sib-pair method likewise indicated no linkage. We conclude that DXS7 is not a major locus for schizophrenia in our collection of pedigrees.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshX Chromosomeen_US
dc.subject.meshY Chromosomeen_US
dc.titleNo evidence for linkage between the X-chromosome marker DXS7 and schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1320600520en_US
dc.identifier.pmid8546163-
dc.identifier.scopuseid_2-s2.0-0028826876en_US
dc.identifier.volume60en_US
dc.identifier.issue5en_US
dc.identifier.spage461en_US
dc.identifier.epage464en_US
dc.identifier.isiWOS:A1995RZ63800019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridOkoro, C=36485184800en_US
dc.identifier.scopusauthoridBell, R=55241037500en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridNanko, S=7006294283en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US

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