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Article: Segregation analysis of complex phenotypes: An application to schizophrenia and auditory P300 latency

TitleSegregation analysis of complex phenotypes: An application to schizophrenia and auditory P300 latency
Authors
Issue Date1994
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
Citation
Psychiatric Genetics, 1994, v. 4 n. 1, p. 29-38 How to Cite?
AbstractTraditional models of the genetic transmission of human diseases have often assumed that the phenotype is a simple dichotomous trait, which is unrealistic for many psychiatric conditions, and may result in loss of valuable information. We describe a new model for complex phenotypes, implemented in the program COMDS, which subclassifies normal and affected individuals into polychotomies correlated with the underlying genetic liability to the disorder. The model is applied to 18 Scottish pedigrees ascertained for schizophrenia, in which auditory P300 latency had been measured as a possible correlate of the genetic predisposition to schizophrenia. The results suggest that there may be a major locus for schizophrenia, but that there are also other familial determinants, possibly a second modifier locus. In addition, the results indicate that auditory P300 latency may be a useful measure of the genetic predisposition to schizophrenia among asymptomatic relatives, although the relationship between P300 latency and the degree of genetic predisposition in clinical cases was not significant, presumably because other factors are operating on P300 latency. Because of the possible selection biases in this sample, there is a need to replicate these findings in systematically ascertained pedigrees.
Persistent Identifierhttp://hdl.handle.net/10722/175700
ISSN
2015 Impact Factor: 1.736
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorMorton, NEen_US
dc.contributor.authorMuir, WJen_US
dc.contributor.authorWalker, Men_US
dc.contributor.authorCollins, Aen_US
dc.contributor.authorShields, DCen_US
dc.contributor.authorSt Clair, DMen_US
dc.contributor.authorBlackwood, DHRen_US
dc.date.accessioned2012-11-26T09:00:35Z-
dc.date.available2012-11-26T09:00:35Z-
dc.date.issued1994en_US
dc.identifier.citationPsychiatric Genetics, 1994, v. 4 n. 1, p. 29-38en_US
dc.identifier.issn0955-8829en_US
dc.identifier.urihttp://hdl.handle.net/10722/175700-
dc.description.abstractTraditional models of the genetic transmission of human diseases have often assumed that the phenotype is a simple dichotomous trait, which is unrealistic for many psychiatric conditions, and may result in loss of valuable information. We describe a new model for complex phenotypes, implemented in the program COMDS, which subclassifies normal and affected individuals into polychotomies correlated with the underlying genetic liability to the disorder. The model is applied to 18 Scottish pedigrees ascertained for schizophrenia, in which auditory P300 latency had been measured as a possible correlate of the genetic predisposition to schizophrenia. The results suggest that there may be a major locus for schizophrenia, but that there are also other familial determinants, possibly a second modifier locus. In addition, the results indicate that auditory P300 latency may be a useful measure of the genetic predisposition to schizophrenia among asymptomatic relatives, although the relationship between P300 latency and the degree of genetic predisposition in clinical cases was not significant, presumably because other factors are operating on P300 latency. Because of the possible selection biases in this sample, there is a need to replicate these findings in systematically ascertained pedigrees.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.comen_US
dc.relation.ispartofPsychiatric Geneticsen_US
dc.subject.meshDiscriminant Analysisen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshEvoked Potentials, Auditory - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshReaction Time - Geneticsen_US
dc.subject.meshSchizophrenia - Genetics - Physiopathologyen_US
dc.titleSegregation analysis of complex phenotypes: An application to schizophrenia and auditory P300 latencyen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00041444-199421000-00005-
dc.identifier.pmid8049901-
dc.identifier.scopuseid_2-s2.0-0028212541en_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage29en_US
dc.identifier.epage38en_US
dc.identifier.isiWOS:A1994NH68800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridMorton, NE=7202900347en_US
dc.identifier.scopusauthoridMuir, WJ=7201565508en_US
dc.identifier.scopusauthoridWalker, M=7403869043en_US
dc.identifier.scopusauthoridCollins, A=7403183390en_US
dc.identifier.scopusauthoridShields, DC=7102451013en_US
dc.identifier.scopusauthoridSt Clair, DM=35354078200en_US
dc.identifier.scopusauthoridBlackwood, DHR=7006606466en_US

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