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Article: Structural characterization of the micelle-vesicle transition in lecithin- bile salt solutions

TitleStructural characterization of the micelle-vesicle transition in lecithin- bile salt solutions
Authors
Issue Date1994
PublisherCell Press. The Journal's web site is located at http://www.cell.com/biophysj/
Citation
Biophysical Journal, 1994, v. 67 n. 4, p. 1733-1742 How to Cite?
AbstractSmall-angle neutron scattering (SANS) and dynamic light scattering (QLS) are used to characterize the aggregates found upon dilution of mixed lecithin-bile salt micelles. Molar ratios of lecithin (L) to taurocholate (TC) studied varied from 0.1 to 1, and one series contained cholesterol (Ch). Mixed aggregates of L and taurodeoxycholate (TDC) at ratios of 0.4 and 1 were also examined. In all cases the micelles are cylindrical or globular and elongate upon dilution. The radius of the mixed micelles varies only slightly with the overall composition of lecithin and bile salt which indicates that the composition of the cylindrical micelle body is nearly constant. The transition from micelles to vesicles is a smooth transformation involving a region where micelles and vesicles coexist. SANS measurements are more sensitive to the presence of two aggregate populations than QLS. Beyond the coexistence region the vesicle size and degree of polydispersity decrease with dilution. Incorporation of a small amount of cholesterol in the lipid mixture does not affect the sequence of observed aggregate structures.
Persistent Identifierhttp://hdl.handle.net/10722/175697
ISSN
2015 Impact Factor: 3.632
2015 SCImago Journal Rankings: 2.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLong, MAen_US
dc.contributor.authorKaler, EWen_US
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:34Z-
dc.date.available2012-11-26T09:00:34Z-
dc.date.issued1994en_US
dc.identifier.citationBiophysical Journal, 1994, v. 67 n. 4, p. 1733-1742en_US
dc.identifier.issn0006-3495en_US
dc.identifier.urihttp://hdl.handle.net/10722/175697-
dc.description.abstractSmall-angle neutron scattering (SANS) and dynamic light scattering (QLS) are used to characterize the aggregates found upon dilution of mixed lecithin-bile salt micelles. Molar ratios of lecithin (L) to taurocholate (TC) studied varied from 0.1 to 1, and one series contained cholesterol (Ch). Mixed aggregates of L and taurodeoxycholate (TDC) at ratios of 0.4 and 1 were also examined. In all cases the micelles are cylindrical or globular and elongate upon dilution. The radius of the mixed micelles varies only slightly with the overall composition of lecithin and bile salt which indicates that the composition of the cylindrical micelle body is nearly constant. The transition from micelles to vesicles is a smooth transformation involving a region where micelles and vesicles coexist. SANS measurements are more sensitive to the presence of two aggregate populations than QLS. Beyond the coexistence region the vesicle size and degree of polydispersity decrease with dilution. Incorporation of a small amount of cholesterol in the lipid mixture does not affect the sequence of observed aggregate structures.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/biophysj/en_US
dc.relation.ispartofBiophysical Journalen_US
dc.subject.meshBile Acids And Salts - Chemistryen_US
dc.subject.meshCholesterol - Chemistryen_US
dc.subject.meshKineticsen_US
dc.subject.meshLighten_US
dc.subject.meshLipid Bilayersen_US
dc.subject.meshMathematicsen_US
dc.subject.meshMicellesen_US
dc.subject.meshModels, Theoreticalen_US
dc.subject.meshNeutronsen_US
dc.subject.meshPhosphatidylcholines - Chemistryen_US
dc.subject.meshScattering, Radiationen_US
dc.subject.meshSolutionsen_US
dc.subject.meshTaurocholic Acid - Chemistryen_US
dc.subject.meshTaurodeoxycholic Acid - Chemistryen_US
dc.titleStructural characterization of the micelle-vesicle transition in lecithin- bile salt solutionsen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-3495(94)80647-2-
dc.identifier.pmid7819505-
dc.identifier.scopuseid_2-s2.0-0028093488en_US
dc.identifier.volume67en_US
dc.identifier.issue4en_US
dc.identifier.spage1733en_US
dc.identifier.epage1742en_US
dc.identifier.isiWOS:A1994PJ13100037-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLong, MA=7203019679en_US
dc.identifier.scopusauthoridKaler, EW=7007157989en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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