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- Publisher Website: 10.1016/S0006-3495(94)80647-2
- Scopus: eid_2-s2.0-0028093488
- PMID: 7819505
- WOS: WOS:A1994PJ13100037
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Article: Structural characterization of the micelle-vesicle transition in lecithin- bile salt solutions
Title | Structural characterization of the micelle-vesicle transition in lecithin- bile salt solutions |
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Authors | |
Issue Date | 1994 |
Publisher | Cell Press. The Journal's web site is located at http://www.cell.com/biophysj/ |
Citation | Biophysical Journal, 1994, v. 67 n. 4, p. 1733-1742 How to Cite? |
Abstract | Small-angle neutron scattering (SANS) and dynamic light scattering (QLS) are used to characterize the aggregates found upon dilution of mixed lecithin-bile salt micelles. Molar ratios of lecithin (L) to taurocholate (TC) studied varied from 0.1 to 1, and one series contained cholesterol (Ch). Mixed aggregates of L and taurodeoxycholate (TDC) at ratios of 0.4 and 1 were also examined. In all cases the micelles are cylindrical or globular and elongate upon dilution. The radius of the mixed micelles varies only slightly with the overall composition of lecithin and bile salt which indicates that the composition of the cylindrical micelle body is nearly constant. The transition from micelles to vesicles is a smooth transformation involving a region where micelles and vesicles coexist. SANS measurements are more sensitive to the presence of two aggregate populations than QLS. Beyond the coexistence region the vesicle size and degree of polydispersity decrease with dilution. Incorporation of a small amount of cholesterol in the lipid mixture does not affect the sequence of observed aggregate structures. |
Persistent Identifier | http://hdl.handle.net/10722/175697 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.188 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Long, MA | en_US |
dc.contributor.author | Kaler, EW | en_US |
dc.contributor.author | Lee, SP | en_US |
dc.date.accessioned | 2012-11-26T09:00:34Z | - |
dc.date.available | 2012-11-26T09:00:34Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Biophysical Journal, 1994, v. 67 n. 4, p. 1733-1742 | en_US |
dc.identifier.issn | 0006-3495 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175697 | - |
dc.description.abstract | Small-angle neutron scattering (SANS) and dynamic light scattering (QLS) are used to characterize the aggregates found upon dilution of mixed lecithin-bile salt micelles. Molar ratios of lecithin (L) to taurocholate (TC) studied varied from 0.1 to 1, and one series contained cholesterol (Ch). Mixed aggregates of L and taurodeoxycholate (TDC) at ratios of 0.4 and 1 were also examined. In all cases the micelles are cylindrical or globular and elongate upon dilution. The radius of the mixed micelles varies only slightly with the overall composition of lecithin and bile salt which indicates that the composition of the cylindrical micelle body is nearly constant. The transition from micelles to vesicles is a smooth transformation involving a region where micelles and vesicles coexist. SANS measurements are more sensitive to the presence of two aggregate populations than QLS. Beyond the coexistence region the vesicle size and degree of polydispersity decrease with dilution. Incorporation of a small amount of cholesterol in the lipid mixture does not affect the sequence of observed aggregate structures. | en_US |
dc.language | eng | en_US |
dc.publisher | Cell Press. The Journal's web site is located at http://www.cell.com/biophysj/ | en_US |
dc.relation.ispartof | Biophysical Journal | en_US |
dc.subject.mesh | Bile Acids And Salts - Chemistry | en_US |
dc.subject.mesh | Cholesterol - Chemistry | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Light | en_US |
dc.subject.mesh | Lipid Bilayers | en_US |
dc.subject.mesh | Mathematics | en_US |
dc.subject.mesh | Micelles | en_US |
dc.subject.mesh | Models, Theoretical | en_US |
dc.subject.mesh | Neutrons | en_US |
dc.subject.mesh | Phosphatidylcholines - Chemistry | en_US |
dc.subject.mesh | Scattering, Radiation | en_US |
dc.subject.mesh | Solutions | en_US |
dc.subject.mesh | Taurocholic Acid - Chemistry | en_US |
dc.subject.mesh | Taurodeoxycholic Acid - Chemistry | en_US |
dc.title | Structural characterization of the micelle-vesicle transition in lecithin- bile salt solutions | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0006-3495(94)80647-2 | - |
dc.identifier.pmid | 7819505 | - |
dc.identifier.scopus | eid_2-s2.0-0028093488 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 1733 | en_US |
dc.identifier.epage | 1742 | en_US |
dc.identifier.isi | WOS:A1994PJ13100037 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Long, MA=7203019679 | en_US |
dc.identifier.scopusauthorid | Kaler, EW=7007157989 | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.issnl | 0006-3495 | - |