File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Age at onset, sex, and familial psychiatric morbidity in schizophrenia. Camberwell collaborative psychosis study

TitleAge at onset, sex, and familial psychiatric morbidity in schizophrenia. Camberwell collaborative psychosis study
Authors
Issue Date1994
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1994, v. 165 OCT., p. 466-473 How to Cite?
AbstractBackground. Although a genetic component in schizophrenia is well established, it is likely that the contribution of genetic factors is not constant for all cases. Several recent studies have found that the relatives of female or early onset schizophrenic patients have an increased risk of schizophrenia, compared to relatives of male or late onset cases. These hypotheses are tested in the current study. Method. A family study design was employed; the probands were 195 patients with functional psychosis admitted to three south London hospitals, diagnosed using Research Diagnostic Criteria (RDC), and assessed using the Present State Examination (PSE). Information on their relatives was obtained by personal interview of the mother of the proband, and from medical records. Psychiatric diagnoses were made using Family History - Research Diagnostic Criteria (FH-RDC), blind to proband information. Results. There was a tendency for homotypia in the form of psychosis within families. The lifetime risk of schizophrenia in the first degree relatives of schizophrenic probands, and the risk of bipolar disorder in the first degree relatives of bipolar probands, were 5-10 times higher than reported population risks. Relatives of female and early onset (< 22 years) schizophrenic probands had higher risk of schizophrenia than relatives of male and late onset schizophrenic probands. However, this effect was compensated in part by an excess of non-schizophrenic psychoses in the relatives of male probands. Conclusions. These results suggest a high familial, possibly genetic, loading in female and early onset schizophrenia, but do not resolve the question of heterogeneity within schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/175690
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorJones, Pen_US
dc.contributor.authorRussell, Aen_US
dc.contributor.authorGilvarry, Ken_US
dc.contributor.authorBebbington, Pen_US
dc.contributor.authorLewis, Sen_US
dc.contributor.authorToone, Ben_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:00:31Z-
dc.date.available2012-11-26T09:00:31Z-
dc.date.issued1994en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1994, v. 165 OCT., p. 466-473en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175690-
dc.description.abstractBackground. Although a genetic component in schizophrenia is well established, it is likely that the contribution of genetic factors is not constant for all cases. Several recent studies have found that the relatives of female or early onset schizophrenic patients have an increased risk of schizophrenia, compared to relatives of male or late onset cases. These hypotheses are tested in the current study. Method. A family study design was employed; the probands were 195 patients with functional psychosis admitted to three south London hospitals, diagnosed using Research Diagnostic Criteria (RDC), and assessed using the Present State Examination (PSE). Information on their relatives was obtained by personal interview of the mother of the proband, and from medical records. Psychiatric diagnoses were made using Family History - Research Diagnostic Criteria (FH-RDC), blind to proband information. Results. There was a tendency for homotypia in the form of psychosis within families. The lifetime risk of schizophrenia in the first degree relatives of schizophrenic probands, and the risk of bipolar disorder in the first degree relatives of bipolar probands, were 5-10 times higher than reported population risks. Relatives of female and early onset (< 22 years) schizophrenic probands had higher risk of schizophrenia than relatives of male and late onset schizophrenic probands. However, this effect was compensated in part by an excess of non-schizophrenic psychoses in the relatives of male probands. Conclusions. These results suggest a high familial, possibly genetic, loading in female and early onset schizophrenia, but do not resolve the question of heterogeneity within schizophrenia.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshBipolar Disorder - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitalizationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPsychiatric Status Rating Scales - Statistics & Numerical Dataen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshSex Factorsen_US
dc.titleAge at onset, sex, and familial psychiatric morbidity in schizophrenia. Camberwell collaborative psychosis studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.165.4.466-
dc.identifier.pmid7804660-
dc.identifier.scopuseid_2-s2.0-0028023288en_US
dc.identifier.volume165en_US
dc.identifier.issueOCT.en_US
dc.identifier.spage466en_US
dc.identifier.epage473en_US
dc.identifier.isiWOS:A1994PL75200007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridJones, P=36078972900en_US
dc.identifier.scopusauthoridRussell, A=35556811900en_US
dc.identifier.scopusauthoridGilvarry, K=6508391739en_US
dc.identifier.scopusauthoridBebbington, P=7102209922en_US
dc.identifier.scopusauthoridLewis, S=7404041267en_US
dc.identifier.scopusauthoridToone, B=7006068925en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats