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Article: Using risk calculation to implement an extended relative pair analysis

TitleUsing risk calculation to implement an extended relative pair analysis
Authors
Issue Date1994
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 1994, v. 58 n. 2, p. 151-162 How to Cite?
AbstractA new nonparametric method of linkage analysis is described based on identity by descent relationships between all pairs of affected relatives within a pedigree. This approach is an extension of ESPA, which only uses information from pairs of affected siblings. The new method, called ERPA, uses the risk calculation facilities of the LINKAGE programs to obtain the necessary information in a fashion which is simple to implement and which automatically generalizes to allow for marker loci which may be multiple, non-codominant and sex-linked. We have investigated the relative performance of ERPA, ESPA and the lod score method on simulated data. ERPA appears to be more sensitive than ESPA for detecting linkage in pedigrees with small sibships, though both nonparametric methods are inferior to the lod score method when the true mode of transmission can be specified.
Persistent Identifierhttp://hdl.handle.net/10722/175689
ISSN
2015 Impact Factor: 1.889
2015 SCImago Journal Rankings: 1.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCurtis, Den_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:00:31Z-
dc.date.available2012-11-26T09:00:31Z-
dc.date.issued1994en_US
dc.identifier.citationAnnals Of Human Genetics, 1994, v. 58 n. 2, p. 151-162en_US
dc.identifier.issn0003-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/175689-
dc.description.abstractA new nonparametric method of linkage analysis is described based on identity by descent relationships between all pairs of affected relatives within a pedigree. This approach is an extension of ESPA, which only uses information from pairs of affected siblings. The new method, called ERPA, uses the risk calculation facilities of the LINKAGE programs to obtain the necessary information in a fashion which is simple to implement and which automatically generalizes to allow for marker loci which may be multiple, non-codominant and sex-linked. We have investigated the relative performance of ERPA, ESPA and the lod score method on simulated data. ERPA appears to be more sensitive than ESPA for detecting linkage in pedigrees with small sibships, though both nonparametric methods are inferior to the lod score method when the true mode of transmission can be specified.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_US
dc.relation.ispartofAnnals of Human Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshLod Scoreen_US
dc.subject.meshPedigreeen_US
dc.subject.meshRisken_US
dc.titleUsing risk calculation to implement an extended relative pair analysisen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1469-1809.1994.tb01884.x-
dc.identifier.pmid7979159-
dc.identifier.scopuseid_2-s2.0-0028022079en_US
dc.identifier.volume58en_US
dc.identifier.issue2en_US
dc.identifier.spage151en_US
dc.identifier.epage162en_US
dc.identifier.isiWOS:A1994PB63800008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCurtis, D=14633020700en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US

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