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Article: Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson)

TitleBile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson)
Authors
Issue Date1991
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/
Citation
Journal Of Lipid Research, 1991, v. 32 n. 9, p. 1417-1427 How to Cite?
AbstractFree vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate. In order to exclude a microbial involvement in its formation (i.e., secondary origin) four sets of experiments were performed. It was found that a) the level of vulpecholic acid remained unchanged in the bile of opossums fed with neomycin and kanamycin for 7 days prior to bile collection; b) it also remained unchanged after long bile drainage; c) in opossums prepared with biliary cannula, intraportally injected [24- 14C]chenodeoxycholic acid was transformed to [24- 14C]vulpecholic acid; and d) in a similar experiment, the detectable transformation of [1α,2α- 3H 2]cholesterol to vulpecholic acid was observed. In experiment c) 28-66% of the administered radioactivity was secreted in 2 h in the form of free biliary vulpecholic and chenodeoxycholic acids. Only a trace amount of the corresponding taurine conjugates (~0.4%) was formed. Moreover, rapidly declining specific radioactivity of the unconjugated chenodeoxycholic acid indicated its probable participation in the native formation of vulpecholic acid.
Persistent Identifierhttp://hdl.handle.net/10722/175664
ISSN
2015 Impact Factor: 4.368
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSt Pyrek, Jen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorThomsen, Len_US
dc.contributor.authorTasmanJones, Cen_US
dc.contributor.authorLeydon, Ben_US
dc.date.accessioned2012-11-26T09:00:20Z-
dc.date.available2012-11-26T09:00:20Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Lipid Research, 1991, v. 32 n. 9, p. 1417-1427en_US
dc.identifier.issn0022-2275en_US
dc.identifier.urihttp://hdl.handle.net/10722/175664-
dc.description.abstractFree vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate. In order to exclude a microbial involvement in its formation (i.e., secondary origin) four sets of experiments were performed. It was found that a) the level of vulpecholic acid remained unchanged in the bile of opossums fed with neomycin and kanamycin for 7 days prior to bile collection; b) it also remained unchanged after long bile drainage; c) in opossums prepared with biliary cannula, intraportally injected [24- 14C]chenodeoxycholic acid was transformed to [24- 14C]vulpecholic acid; and d) in a similar experiment, the detectable transformation of [1α,2α- 3H 2]cholesterol to vulpecholic acid was observed. In experiment c) 28-66% of the administered radioactivity was secreted in 2 h in the form of free biliary vulpecholic and chenodeoxycholic acids. Only a trace amount of the corresponding taurine conjugates (~0.4%) was formed. Moreover, rapidly declining specific radioactivity of the unconjugated chenodeoxycholic acid indicated its probable participation in the native formation of vulpecholic acid.en_US
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/en_US
dc.relation.ispartofJournal of Lipid Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile Acids And Salts - Metabolismen_US
dc.subject.meshChenodeoxycholic Acid - Metabolismen_US
dc.subject.meshCholic Acids - Chemistry - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshOpossums - Metabolismen_US
dc.subject.meshTaurine - Metabolismen_US
dc.titleBile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson)en_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1753212-
dc.identifier.scopuseid_2-s2.0-0026043882en_US
dc.identifier.volume32en_US
dc.identifier.issue9en_US
dc.identifier.spage1417en_US
dc.identifier.epage1427en_US
dc.identifier.isiWOS:A1991GH89100004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSt Pyrek, J=6701658950en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridThomsen, L=55107476400en_US
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_US
dc.identifier.scopusauthoridLeydon, B=36822068800en_US

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