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- Scopus: eid_2-s2.0-0026043882
- PMID: 1753212
- WOS: WOS:A1991GH89100004
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Article: Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson)
Title | Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson) |
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Authors | |
Keywords | Australian opossum cholesterol dehydro-vulpecholic acid |
Issue Date | 1991 |
Publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/ |
Citation | Journal Of Lipid Research, 1991, v. 32 n. 9, p. 1417-1427 How to Cite? |
Abstract | Free vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate. In order to exclude a microbial involvement in its formation (i.e., secondary origin) four sets of experiments were performed. It was found that a) the level of vulpecholic acid remained unchanged in the bile of opossums fed with neomycin and kanamycin for 7 days prior to bile collection; b) it also remained unchanged after long bile drainage; c) in opossums prepared with biliary cannula, intraportally injected [24- 14C]chenodeoxycholic acid was transformed to [24- 14C]vulpecholic acid; and d) in a similar experiment, the detectable transformation of [1α,2α- 3H 2]cholesterol to vulpecholic acid was observed. In experiment c) 28-66% of the administered radioactivity was secreted in 2 h in the form of free biliary vulpecholic and chenodeoxycholic acids. Only a trace amount of the corresponding taurine conjugates (~0.4%) was formed. Moreover, rapidly declining specific radioactivity of the unconjugated chenodeoxycholic acid indicated its probable participation in the native formation of vulpecholic acid. |
Persistent Identifier | http://hdl.handle.net/10722/175664 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.090 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | St Pyrek, J | en_US |
dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Thomsen, L | en_US |
dc.contributor.author | TasmanJones, C | en_US |
dc.contributor.author | Leydon, B | en_US |
dc.date.accessioned | 2012-11-26T09:00:20Z | - |
dc.date.available | 2012-11-26T09:00:20Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Journal Of Lipid Research, 1991, v. 32 n. 9, p. 1417-1427 | en_US |
dc.identifier.issn | 0022-2275 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175664 | - |
dc.description.abstract | Free vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate. In order to exclude a microbial involvement in its formation (i.e., secondary origin) four sets of experiments were performed. It was found that a) the level of vulpecholic acid remained unchanged in the bile of opossums fed with neomycin and kanamycin for 7 days prior to bile collection; b) it also remained unchanged after long bile drainage; c) in opossums prepared with biliary cannula, intraportally injected [24- 14C]chenodeoxycholic acid was transformed to [24- 14C]vulpecholic acid; and d) in a similar experiment, the detectable transformation of [1α,2α- 3H 2]cholesterol to vulpecholic acid was observed. In experiment c) 28-66% of the administered radioactivity was secreted in 2 h in the form of free biliary vulpecholic and chenodeoxycholic acids. Only a trace amount of the corresponding taurine conjugates (~0.4%) was formed. Moreover, rapidly declining specific radioactivity of the unconjugated chenodeoxycholic acid indicated its probable participation in the native formation of vulpecholic acid. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/ | en_US |
dc.relation.ispartof | Journal of Lipid Research | en_US |
dc.subject | Australian opossum | - |
dc.subject | cholesterol | - |
dc.subject | dehydro-vulpecholic acid | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bile Acids And Salts - Metabolism | en_US |
dc.subject.mesh | Chenodeoxycholic Acid - Metabolism | en_US |
dc.subject.mesh | Cholic Acids - Chemistry - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Liver - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Opossums - Metabolism | en_US |
dc.subject.mesh | Taurine - Metabolism | en_US |
dc.title | Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson) | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1753212 | - |
dc.identifier.scopus | eid_2-s2.0-0026043882 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.spage | 1417 | en_US |
dc.identifier.epage | 1427 | en_US |
dc.identifier.isi | WOS:A1991GH89100004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | St Pyrek, J=6701658950 | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Thomsen, L=55107476400 | en_US |
dc.identifier.scopusauthorid | TasmanJones, C=7003303326 | en_US |
dc.identifier.scopusauthorid | Leydon, B=36822068800 | en_US |
dc.identifier.issnl | 0022-2275 | - |