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Article: Ceftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate

TitleCeftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate
Authors
Issue Date1991
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1991, v. 100 n. 6, p. 1665-1670 How to Cite?
AbstractCeftriaxone, a third-generation cephalosporin, is partially excreted into bile. With its clinical use, the formation of gallbladder sludge detected by ultrasonography has been reported. Four surgical specimens were examined and no gallstones were found. Instead, fine precipitates of 20-250 μm were present. Microscopically, there was a small number of cholesterol monohydrate crystals and bilirubin granules among an abundant amount of granular-crystalline material that was not morphologically cholesterol monohydrate crystals. The chemical composition of the precipitates (n = 4) was determined. There was a small amount of cholesterol (1.7% ± 0.8%) and bilirubin (13.9% ± 0.74%). The major component of the precipitate was a residue. On further analysis using thin-layer chromatography, high-performance liquid chromatography, and electron microprobe analysis, the residue was identified as a calcium salt of ceftriaxone. The residue also had identical crystal morphology and chromatographic elution profile as authentic calcium-ceftriaxone standards. It is concluded that ceftriaxone, after excretion and being concentrated in the gallbladder bile, can form a precipitate. The major constituent has been identified as a ceftriaxone-calcium salt.
Persistent Identifierhttp://hdl.handle.net/10722/175659
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPark, HZen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorSchy, ALen_US
dc.date.accessioned2012-11-26T09:00:19Z-
dc.date.available2012-11-26T09:00:19Z-
dc.date.issued1991en_US
dc.identifier.citationGastroenterology, 1991, v. 100 n. 6, p. 1665-1670en_US
dc.identifier.issn0016-5085en_US
dc.identifier.urihttp://hdl.handle.net/10722/175659-
dc.description.abstractCeftriaxone, a third-generation cephalosporin, is partially excreted into bile. With its clinical use, the formation of gallbladder sludge detected by ultrasonography has been reported. Four surgical specimens were examined and no gallstones were found. Instead, fine precipitates of 20-250 μm were present. Microscopically, there was a small number of cholesterol monohydrate crystals and bilirubin granules among an abundant amount of granular-crystalline material that was not morphologically cholesterol monohydrate crystals. The chemical composition of the precipitates (n = 4) was determined. There was a small amount of cholesterol (1.7% ± 0.8%) and bilirubin (13.9% ± 0.74%). The major component of the precipitate was a residue. On further analysis using thin-layer chromatography, high-performance liquid chromatography, and electron microprobe analysis, the residue was identified as a calcium salt of ceftriaxone. The residue also had identical crystal morphology and chromatographic elution profile as authentic calcium-ceftriaxone standards. It is concluded that ceftriaxone, after excretion and being concentrated in the gallbladder bile, can form a precipitate. The major constituent has been identified as a ceftriaxone-calcium salt.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_US
dc.relation.ispartofGastroenterologyen_US
dc.subject.meshBile - Chemistryen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCeftriaxone - Adverse Effects - Metabolismen_US
dc.subject.meshChemical Precipitationen_US
dc.subject.meshCholelithiasis - Ultrasonographyen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshChromatography, Thin Layeren_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshElectron Probe Microanalysisen_US
dc.subject.meshGallbladder - Ultrasonographyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSpectrophotometry, Infrareden_US
dc.titleCeftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitateen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2019372-
dc.identifier.scopuseid_2-s2.0-0025877177en_US
dc.identifier.volume100en_US
dc.identifier.issue6en_US
dc.identifier.spage1665en_US
dc.identifier.epage1670en_US
dc.identifier.isiWOS:A1991FL37500024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPark, HZ=7601570519en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridSchy, AL=6604068075en_US

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