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Article: Effects of Trimoprostil, a prostaglandin E 2 analogue, on human gastric acid secretion and soluble mucin output

TitleEffects of Trimoprostil, a prostaglandin E 2 analogue, on human gastric acid secretion and soluble mucin output
Authors
Issue Date1987
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECI
Citation
European Journal Of Clinical Investigation, 1987, v. 17 n. 1, p. 1-6 How to Cite?
AbstractWe have studied the effects of Trimoprostil, a prostaglandin E 2 analogue, on human gastric acid and soluble mucus output using human subjects. This compound caused anti-secretory effects on both basal as well as histamine-stimulated gastric acid secretion in a dose-dependent manner. There was a simultaneous increase in total mucus output. When the secreted mucus was fractionated by Sepharose CL-2B gel chromatography, most of the basal gastric mucin was shown to be in the polymeric form (mol wt 2 x 10 6), whereas after histamine stimulation the mucin was mostly in the subunit form (mol wt 0.5 x 10 6). The gastric mucin, after stimulation using low doses of prostaglandin, was mainly in the polymeric form; but after high doses, the subunit form predominated. These observations are important in the understanding of physiological and pharmacological control of gastric mucus output with regard to its chemical composition and molecular heterogeneity, and provide further insight into the rational clinical use of the prostaglandins for gastroduodenal diseases.
Persistent Identifierhttp://hdl.handle.net/10722/175645
ISSN
2015 Impact Factor: 2.687
2015 SCImago Journal Rankings: 1.255
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorNicholls, JFen_US
dc.contributor.authorRobertson, AMen_US
dc.date.accessioned2012-11-26T09:00:15Z-
dc.date.available2012-11-26T09:00:15Z-
dc.date.issued1987en_US
dc.identifier.citationEuropean Journal Of Clinical Investigation, 1987, v. 17 n. 1, p. 1-6en_US
dc.identifier.issn0014-2972en_US
dc.identifier.urihttp://hdl.handle.net/10722/175645-
dc.description.abstractWe have studied the effects of Trimoprostil, a prostaglandin E 2 analogue, on human gastric acid and soluble mucus output using human subjects. This compound caused anti-secretory effects on both basal as well as histamine-stimulated gastric acid secretion in a dose-dependent manner. There was a simultaneous increase in total mucus output. When the secreted mucus was fractionated by Sepharose CL-2B gel chromatography, most of the basal gastric mucin was shown to be in the polymeric form (mol wt 2 x 10 6), whereas after histamine stimulation the mucin was mostly in the subunit form (mol wt 0.5 x 10 6). The gastric mucin, after stimulation using low doses of prostaglandin, was mainly in the polymeric form; but after high doses, the subunit form predominated. These observations are important in the understanding of physiological and pharmacological control of gastric mucus output with regard to its chemical composition and molecular heterogeneity, and provide further insight into the rational clinical use of the prostaglandins for gastroduodenal diseases.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECIen_US
dc.relation.ispartofEuropean Journal of Clinical Investigationen_US
dc.subject.meshAdulten_US
dc.subject.meshChromatography, Gelen_US
dc.subject.meshDinoprostone - Analogs & Derivativesen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastric Mucins - Analysis - Secretionen_US
dc.subject.meshGastric Mucosa - Drug Effectsen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProstaglandins E, Synthetic - Pharmacologyen_US
dc.titleEffects of Trimoprostil, a prostaglandin E 2 analogue, on human gastric acid secretion and soluble mucin outputen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2362.1987.tb01217.x-
dc.identifier.pmid2436919-
dc.identifier.scopuseid_2-s2.0-0023135509en_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage6en_US
dc.identifier.isiWOS:A1987F994100001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridNicholls, JF=7201464908en_US
dc.identifier.scopusauthoridRobertson, AM=7403044550en_US

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