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Article: Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology

TitleOleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology
Authors
Issue Date1986
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 1986, v. 124 n. 1, p. 18-24 How to Cite?
AbstractFeeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation.
Persistent Identifierhttp://hdl.handle.net/10722/175640
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorTasmanJones, Cen_US
dc.contributor.authorCarlisle, Ven_US
dc.date.accessioned2012-11-26T09:00:14Z-
dc.date.available2012-11-26T09:00:14Z-
dc.date.issued1986en_US
dc.identifier.citationAmerican Journal Of Pathology, 1986, v. 124 n. 1, p. 18-24en_US
dc.identifier.issn0002-9440en_US
dc.identifier.urihttp://hdl.handle.net/10722/175640-
dc.description.abstractFeeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation.en_US
dc.languageengen_US
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_US
dc.relation.ispartofAmerican Journal of Pathologyen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile Acids And Salts - Analysis - Biosynthesisen_US
dc.subject.meshCholelithiasis - Chemically Induced - Pathologyen_US
dc.subject.meshCholesterol - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Drug Effects - Metabolism - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshOleic Aciden_US
dc.subject.meshOleic Acids - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.titleOleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphologyen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3728645-
dc.identifier.scopuseid_2-s2.0-0022490239en_US
dc.identifier.volume124en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.identifier.epage24en_US
dc.identifier.isiWOS:A1986D198200003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_US
dc.identifier.scopusauthoridCarlisle, V=6602101145en_US

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