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- Publisher Website: 10.1111/j.1440-1681.1980.tb00076.x
- Scopus: eid_2-s2.0-0018849307
- PMID: 7398137
- WOS: WOS:A1980JX34100009
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Article: Tissue distribution of orally administered bismuth in the rat
Title | Tissue distribution of orally administered bismuth in the rat |
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Authors | |
Keywords | Bismuth bismuth toxicity peptic ulcer tissue distribution |
Issue Date | 1980 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1980, v. 7 n. 3, p. 319-324 How to Cite? |
Abstract | A colloidal bismuth preparation, tripotassium dicitrato-bismuthate, was given (172 mg/kg body weight, 6/7 days) to 10 laboratory rats for 14 months. Bismuth was measured by atomic absorption spectrometry in various tissues and the pattern of distribution studied. Bismuth was present in kidney, lung, spleen, liver, brain, heart and skeletal muscles, in descending order of abundance. Hematological data, renal and liver function tests were normal in the bismuth-treated group. The data suggested that chronic ingestion of bismuth in large doses in rats results in absorption and binding to tissues. Absorbed bismuth probably crosses the blood-brain barrier. |
Persistent Identifier | http://hdl.handle.net/10722/175612 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, SP | en_US |
dc.contributor.author | Lim, TH | en_US |
dc.contributor.author | Pybus, J | en_US |
dc.contributor.author | Clarke, AC | en_US |
dc.date.accessioned | 2012-11-26T09:00:08Z | - |
dc.date.available | 2012-11-26T09:00:08Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1980, v. 7 n. 3, p. 319-324 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175612 | - |
dc.description.abstract | A colloidal bismuth preparation, tripotassium dicitrato-bismuthate, was given (172 mg/kg body weight, 6/7 days) to 10 laboratory rats for 14 months. Bismuth was measured by atomic absorption spectrometry in various tissues and the pattern of distribution studied. Bismuth was present in kidney, lung, spleen, liver, brain, heart and skeletal muscles, in descending order of abundance. Hematological data, renal and liver function tests were normal in the bismuth-treated group. The data suggested that chronic ingestion of bismuth in large doses in rats results in absorption and binding to tissues. Absorbed bismuth probably crosses the blood-brain barrier. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | Bismuth | - |
dc.subject | bismuth toxicity | - |
dc.subject | peptic ulcer | - |
dc.subject | tissue distribution | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bilirubin - Blood | en_US |
dc.subject.mesh | Bismuth - Blood - Metabolism | en_US |
dc.subject.mesh | Blood Cell Count | en_US |
dc.subject.mesh | Enzymes - Blood | en_US |
dc.subject.mesh | Hemoglobins - Metabolism | en_US |
dc.subject.mesh | Leukocyte Count | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Reticulocytes | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.subject.mesh | Urea - Blood | en_US |
dc.title | Tissue distribution of orally administered bismuth in the rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, SP: sumlee@hku.hk | en_US |
dc.identifier.authority | Lee, SP=rp01351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1980.tb00076.x | - |
dc.identifier.pmid | 7398137 | - |
dc.identifier.scopus | eid_2-s2.0-0018849307 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 319 | en_US |
dc.identifier.epage | 324 | en_US |
dc.identifier.isi | WOS:A1980JX34100009 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Lee, SP=7601417497 | en_US |
dc.identifier.scopusauthorid | Lim, TH=7401710711 | en_US |
dc.identifier.scopusauthorid | Pybus, J=6603626624 | en_US |
dc.identifier.scopusauthorid | Clarke, AC=7403682654 | en_US |
dc.identifier.issnl | 0305-1870 | - |