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Article: Tissue distribution of orally administered bismuth in the rat

TitleTissue distribution of orally administered bismuth in the rat
Authors
Issue Date1980
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1980, v. 7 n. 3, p. 319-324 How to Cite?
AbstractA colloidal bismuth preparation, tripotassium dicitrato-bismuthate, was given (172 mg/kg body weight, 6/7 days) to 10 laboratory rats for 14 months. Bismuth was measured by atomic absorption spectrometry in various tissues and the pattern of distribution studied. Bismuth was present in kidney, lung, spleen, liver, brain, heart and skeletal muscles, in descending order of abundance. Hematological data, renal and liver function tests were normal in the bismuth-treated group. The data suggested that chronic ingestion of bismuth in large doses in rats results in absorption and binding to tissues. Absorbed bismuth probably crosses the blood-brain barrier.
Persistent Identifierhttp://hdl.handle.net/10722/175612
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorLim, THen_US
dc.contributor.authorPybus, Jen_US
dc.contributor.authorClarke, ACen_US
dc.date.accessioned2012-11-26T09:00:08Z-
dc.date.available2012-11-26T09:00:08Z-
dc.date.issued1980en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1980, v. 7 n. 3, p. 319-324en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/175612-
dc.description.abstractA colloidal bismuth preparation, tripotassium dicitrato-bismuthate, was given (172 mg/kg body weight, 6/7 days) to 10 laboratory rats for 14 months. Bismuth was measured by atomic absorption spectrometry in various tissues and the pattern of distribution studied. Bismuth was present in kidney, lung, spleen, liver, brain, heart and skeletal muscles, in descending order of abundance. Hematological data, renal and liver function tests were normal in the bismuth-treated group. The data suggested that chronic ingestion of bismuth in large doses in rats results in absorption and binding to tissues. Absorbed bismuth probably crosses the blood-brain barrier.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBilirubin - Blooden_US
dc.subject.meshBismuth - Blood - Metabolismen_US
dc.subject.meshBlood Cell Counten_US
dc.subject.meshEnzymes - Blooden_US
dc.subject.meshHemoglobins - Metabolismen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshReticulocytesen_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshUrea - Blooden_US
dc.titleTissue distribution of orally administered bismuth in the raten_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1980.tb00076.x-
dc.identifier.pmid7398137-
dc.identifier.scopuseid_2-s2.0-0018849307en_US
dc.identifier.volume7en_US
dc.identifier.issue3en_US
dc.identifier.spage319en_US
dc.identifier.epage324en_US
dc.identifier.isiWOS:A1980JX34100009-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridLim, TH=7401710711en_US
dc.identifier.scopusauthoridPybus, J=6603626624en_US
dc.identifier.scopusauthoridClarke, AC=7403682654en_US

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