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Article: Further observations in lincomycin-induced cholelithiasis in guinea-pigs

TitleFurther observations in lincomycin-induced cholelithiasis in guinea-pigs
Authors
Issue Date1980
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 1980, v. 131 n. 2, p. 117-125 How to Cite?
AbstractFurther experiments are reported on Lincomycin-induced cholelithiasis in guinea-pigs. The biochemical events in the bile and blood, and the chemical composition of gallstones, have been studied. The gallstones resemble human pigment stones in chemical composition. the clear hepatic bile and the normality of the bile salt-phospholipid-cholesterol equilibrium, the rise in β-glucuronidase and hexosamine levels with the gallbladder, have reaffirmed that epithelial injury is most probably the primary lithogenic factor. Ligation of the cystic duct and the construction of a common hepatic duct-duodenum bypass did not prevent the development of acute cholecystitis, suggesting the lithogenic factor was mediated through the blood circulation and not through the enterohepatic circulation of bile.
Persistent Identifierhttp://hdl.handle.net/10722/175611
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorScott, AJen_US
dc.date.accessioned2012-11-26T09:00:08Z-
dc.date.available2012-11-26T09:00:08Z-
dc.date.issued1980en_US
dc.identifier.citationJournal Of Pathology, 1980, v. 131 n. 2, p. 117-125en_US
dc.identifier.issn0022-3417en_US
dc.identifier.urihttp://hdl.handle.net/10722/175611-
dc.description.abstractFurther experiments are reported on Lincomycin-induced cholelithiasis in guinea-pigs. The biochemical events in the bile and blood, and the chemical composition of gallstones, have been studied. The gallstones resemble human pigment stones in chemical composition. the clear hepatic bile and the normality of the bile salt-phospholipid-cholesterol equilibrium, the rise in β-glucuronidase and hexosamine levels with the gallbladder, have reaffirmed that epithelial injury is most probably the primary lithogenic factor. Ligation of the cystic duct and the construction of a common hepatic duct-duodenum bypass did not prevent the development of acute cholecystitis, suggesting the lithogenic factor was mediated through the blood circulation and not through the enterohepatic circulation of bile.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_US
dc.relation.ispartofJournal of Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile - Analysisen_US
dc.subject.meshCholelithiasis - Chemically Induced - Metabolism - Pathologyen_US
dc.subject.meshColitis - Pathologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEnterohepatic Circulationen_US
dc.subject.meshErythrocytes - Drug Effects - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucuronidase - Metabolismen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHexosamines - Metabolismen_US
dc.subject.meshIleitis - Pathologyen_US
dc.subject.meshLincomycin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.titleFurther observations in lincomycin-induced cholelithiasis in guinea-pigsen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/path.1711310204-
dc.identifier.pmid7431143-
dc.identifier.scopuseid_2-s2.0-0018821215en_US
dc.identifier.volume131en_US
dc.identifier.issue2en_US
dc.identifier.spage117en_US
dc.identifier.epage125en_US
dc.identifier.isiWOS:A1980KB86400003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridScott, AJ=7403271310en_US

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