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Article: Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury

TitleDihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury
Authors
Issue Date1979
Citation
British Journal Of Experimental Pathology, 1979, v. 60 n. 3, p. 231-238 How to Cite?
AbstractRabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder. In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological change was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells. It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholethiasis.
Persistent Identifierhttp://hdl.handle.net/10722/175610
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorScott, AJen_US
dc.date.accessioned2012-11-26T09:00:07Z-
dc.date.available2012-11-26T09:00:07Z-
dc.date.issued1979en_US
dc.identifier.citationBritish Journal Of Experimental Pathology, 1979, v. 60 n. 3, p. 231-238en_US
dc.identifier.issn0007-1021en_US
dc.identifier.urihttp://hdl.handle.net/10722/175610-
dc.description.abstractRabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder. In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological change was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells. It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholethiasis.en_US
dc.languageengen_US
dc.relation.ispartofBritish Journal of Experimental Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Coagulation - Drug Effectsen_US
dc.subject.meshCholelithiasis - Chemically Induced - Metabolism - Pathologyen_US
dc.subject.meshCholestanol - Toxicityen_US
dc.subject.meshCholesterol - Analogs & Derivativesen_US
dc.subject.meshDeoxycholic Acid - Metabolismen_US
dc.subject.meshEpithelium - Drug Effectsen_US
dc.subject.meshErythrocyte Counten_US
dc.subject.meshErythrocytes - Drug Effects - Ultrastructureen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshOsmolar Concentrationen_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshPotassium - Blooden_US
dc.subject.meshRabbitsen_US
dc.subject.meshSodium - Blooden_US
dc.titleDihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injuryen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid383127-
dc.identifier.scopuseid_2-s2.0-0018772416en_US
dc.identifier.volume60en_US
dc.identifier.issue3en_US
dc.identifier.spage231en_US
dc.identifier.epage238en_US
dc.identifier.isiWOS:A1979HG21100001-
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridScott, AJ=7403271310en_US

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