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Article: Enhanced fluid transport across gallbladder mucosa in experimental cholelithiasis

TitleEnhanced fluid transport across gallbladder mucosa in experimental cholelithiasis
Authors
Issue Date1978
Citation
American Journal Of Physiology Endocrinology Metabolism And Gastrointestinal Physiology, 1978, v. 3 n. 6, p. E575-E578 How to Cite?
AbstractFluid transport of the gallbladder has been studied in two models of experimental cholelithiasis: dihydrocholesterol-induced gallstones in the rabbit and lincomycin-induced gallstones in the guinea pig. Using the noneverted explanted gallbladder of the rabbit and the guinea pig, the transport of luminal to serosal fluid has been quantitated before, during, and after stone formation. The everted gallbladder preparation of the rabbit has also been used to measure fluid transport before and during gallstone formation. In both models, an increased fluid transport was observed in the phase of gallstone induction and a return to normal after stones were formed. This abnormality preceded the appearance of conventional histological features of cholecystitis. There was also a coincidental increase in glycoprotein production from and cell proliferation of the gallbladder epithelium. This enhancement of fluid transfer may play a contributing role in the genesis of gallstones.
Persistent Identifierhttp://hdl.handle.net/10722/175607
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:00:07Z-
dc.date.available2012-11-26T09:00:07Z-
dc.date.issued1978en_US
dc.identifier.citationAmerican Journal Of Physiology Endocrinology Metabolism And Gastrointestinal Physiology, 1978, v. 3 n. 6, p. E575-E578en_US
dc.identifier.issn0363-6100en_US
dc.identifier.urihttp://hdl.handle.net/10722/175607-
dc.description.abstractFluid transport of the gallbladder has been studied in two models of experimental cholelithiasis: dihydrocholesterol-induced gallstones in the rabbit and lincomycin-induced gallstones in the guinea pig. Using the noneverted explanted gallbladder of the rabbit and the guinea pig, the transport of luminal to serosal fluid has been quantitated before, during, and after stone formation. The everted gallbladder preparation of the rabbit has also been used to measure fluid transport before and during gallstone formation. In both models, an increased fluid transport was observed in the phase of gallstone induction and a return to normal after stones were formed. This abnormality preceded the appearance of conventional histological features of cholecystitis. There was also a coincidental increase in glycoprotein production from and cell proliferation of the gallbladder epithelium. This enhancement of fluid transfer may play a contributing role in the genesis of gallstones.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Physiology Endocrinology Metabolism and Gastrointestinal Physiologyen_US
dc.titleEnhanced fluid transport across gallbladder mucosa in experimental cholelithiasisen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0018220937en_US
dc.identifier.volume3en_US
dc.identifier.issue6en_US
dc.identifier.spageE575en_US
dc.identifier.epageE578en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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