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Article: Prevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist

TitlePrevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonist
Authors
Issue Date1978
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 1, p. 61-66 How to Cite?
AbstractIntraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 μmol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d.=0.28): the difference was highly significant (P<0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 μmol/min (s.d.=0.12;P<0.001). Treatment with cimetidine in doses of 100 mg/kg 8-hourly during a 24 h period of restraint prevented the development of acute gastric ulceration in the rat. Pretreatment with cimetidine also protected against the ulcerogenic effects of intragastrically administered bile or lysolecithin. The marked sustained reduction of acid production most probably accounts for the protective effect of cimetidine against ulcer production in the rat stomach.
Persistent Identifierhttp://hdl.handle.net/10722/175604
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.contributor.authorTasmanJones, Cen_US
dc.date.accessioned2012-11-26T09:00:06Z-
dc.date.available2012-11-26T09:00:06Z-
dc.date.issued1978en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1978, v. 5 n. 1, p. 61-66en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/175604-
dc.description.abstractIntraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 μmol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d.=0.28): the difference was highly significant (P<0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 μmol/min (s.d.=0.12;P<0.001). Treatment with cimetidine in doses of 100 mg/kg 8-hourly during a 24 h period of restraint prevented the development of acute gastric ulceration in the rat. Pretreatment with cimetidine also protected against the ulcerogenic effects of intragastrically administered bile or lysolecithin. The marked sustained reduction of acid production most probably accounts for the protective effect of cimetidine against ulcer production in the rat stomach.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBile - Physiologyen_US
dc.subject.meshCimetidine - Pharmacology - Therapeutic Useen_US
dc.subject.meshGastric Juice - Secretionen_US
dc.subject.meshGuanidines - Therapeutic Useen_US
dc.subject.meshLysophosphatidylcholines - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshStomach Ulcer - Chemically Induced - Prevention & Controlen_US
dc.titlePrevention of acute gastric ulceration in the rat by cimetidine, a histamine H2-receptor antagonisten_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1978.tb00652.x-
dc.identifier.pmid639359-
dc.identifier.scopuseid_2-s2.0-0018134601en_US
dc.identifier.volume5en_US
dc.identifier.issue1en_US
dc.identifier.spage61en_US
dc.identifier.epage66en_US
dc.identifier.isiWOS:A1978EM29000008-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridTasmanJones, C=7003303326en_US

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