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Article: Allelic association analysis of dopamine D2, D3, 5-HT2A and GABAg2 receptors and the serotonin transporter genes with heorin abuse in chinese subjects

TitleAllelic association analysis of dopamine D2, D3, 5-HT2A and GABAg2 receptors and the serotonin transporter genes with heorin abuse in chinese subjects
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 520 How to Cite?
AbstractFive candidate genes, the receptors DRD2, DRD3, HTR2A and GABAg2, and the serotonin transporter (5-HTT) were examined for association analysis with heroin abuse. We examined three polymorphisms (promoter -141DC, Ser311Cys, and 'Taq I') in the DRD2, one polymorphism (Ser9Gly) in DRD3, two polymorphisms (promoter -1438G/A and T102C) in HTR2A, two polymorphisms (VNTR and Del/Ins) in 5-HTT gene, and one polymorphism (G3145A) in GABAg2 gene in 121 Chinese heroin addicts and 180 controls. All polymorphisms did not differ significantly for allele, genotype, or haplotype frequencies, except for DRD2 promoter polymorphism (genotype-wise and allele-wise, P = 0.05). An additional 344 subjects with heroin abuse and 118 control were investigated for DRD2 promoter polymorphism. There were no significant difference of genotype or allele frequencies between subjects with heroin abuse and normal controls. However when we divided the sample by route of administration into nasal inhalers and IM or IV injectors, it produced a significant difference between inhaler of heroin and controls (genotype-wise, P=0.006, allele-wise, P=0.016) but not for injectors of heroin (genotype-wise, P=0.81, allelewise, P=0.69). Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABAg2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter -141DC polymorphism.
Persistent Identifierhttp://hdl.handle.net/10722/175594
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:00:04Z-
dc.date.available2012-11-26T09:00:04Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 520en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175594-
dc.description.abstractFive candidate genes, the receptors DRD2, DRD3, HTR2A and GABAg2, and the serotonin transporter (5-HTT) were examined for association analysis with heroin abuse. We examined three polymorphisms (promoter -141DC, Ser311Cys, and 'Taq I') in the DRD2, one polymorphism (Ser9Gly) in DRD3, two polymorphisms (promoter -1438G/A and T102C) in HTR2A, two polymorphisms (VNTR and Del/Ins) in 5-HTT gene, and one polymorphism (G3145A) in GABAg2 gene in 121 Chinese heroin addicts and 180 controls. All polymorphisms did not differ significantly for allele, genotype, or haplotype frequencies, except for DRD2 promoter polymorphism (genotype-wise and allele-wise, P = 0.05). An additional 344 subjects with heroin abuse and 118 control were investigated for DRD2 promoter polymorphism. There were no significant difference of genotype or allele frequencies between subjects with heroin abuse and normal controls. However when we divided the sample by route of administration into nasal inhalers and IM or IV injectors, it produced a significant difference between inhaler of heroin and controls (genotype-wise, P=0.006, allele-wise, P=0.016) but not for injectors of heroin (genotype-wise, P=0.81, allelewise, P=0.69). Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABAg2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter -141DC polymorphism.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleAllelic association analysis of dopamine D2, D3, 5-HT2A and GABAg2 receptors and the serotonin transporter genes with heorin abuse in chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0006706375en_US
dc.identifier.volume96en_US
dc.identifier.issue4en_US
dc.identifier.spage520en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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