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Article: An interstitial fluid transdermal extraction system for continuous glucose monitoring

TitleAn interstitial fluid transdermal extraction system for continuous glucose monitoring
Authors
KeywordsContinuous glucose monitoring
interstitial fluid (ISF)
microfluidic system
transdermal extraction
Issue Date2012
PublisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?reload=true&punumber=84
Citation
Journal Of Microelectromechanical Systems, 2012, v. 21 n. 4, p. 917-925 How to Cite?
AbstractA novel microfluidic system which is fabricated with five polydimethylsiloxane layers for interstitial fluid (ISF) extraction, collection, and measurement toward the application of continuous and real-time glucose monitoring is presented in this paper. The system consists of a micro vacuum generator for ISF transdermal extraction and fluid manipulation, micro chambers for the collection of ISF, micro pneumatic valves for fluid management, and a micro flow sensor for ISF volume measurement. Sequentially controlled by the pneumatic valves, the ISF extraction, collection, and volumetric measurement functions of the system were demonstrated using the stable vacuum generated by the integrated vacuum generator. Through low-frequency ultrasound pretreated full-thickness pig skin, the normal saline solution with different glucose concentrations was transdermally extracted, collected, and measured. The absolute error in the volume measurement of the transdermally extracted ISF analog was less than 0.05 μ L. The microfluidic system makes it possible to realize the clinical application of continuous glucose monitoring based on ISF transdermal extraction technology. © 2012 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/175546
ISSN
2015 Impact Factor: 1.939
2015 SCImago Journal Rankings: 0.847
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Hen_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorRoberts, RCen_HK
dc.contributor.authorXu, Ken_HK
dc.contributor.authorTien, NCen_HK
dc.date.accessioned2012-11-26T08:59:28Z-
dc.date.available2012-11-26T08:59:28Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Microelectromechanical Systems, 2012, v. 21 n. 4, p. 917-925en_HK
dc.identifier.issn1057-7157en_HK
dc.identifier.urihttp://hdl.handle.net/10722/175546-
dc.description.abstractA novel microfluidic system which is fabricated with five polydimethylsiloxane layers for interstitial fluid (ISF) extraction, collection, and measurement toward the application of continuous and real-time glucose monitoring is presented in this paper. The system consists of a micro vacuum generator for ISF transdermal extraction and fluid manipulation, micro chambers for the collection of ISF, micro pneumatic valves for fluid management, and a micro flow sensor for ISF volume measurement. Sequentially controlled by the pneumatic valves, the ISF extraction, collection, and volumetric measurement functions of the system were demonstrated using the stable vacuum generated by the integrated vacuum generator. Through low-frequency ultrasound pretreated full-thickness pig skin, the normal saline solution with different glucose concentrations was transdermally extracted, collected, and measured. The absolute error in the volume measurement of the transdermally extracted ISF analog was less than 0.05 μ L. The microfluidic system makes it possible to realize the clinical application of continuous glucose monitoring based on ISF transdermal extraction technology. © 2012 IEEE.en_HK
dc.languageengen_US
dc.publisherIEEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?reload=true&punumber=84-
dc.relation.ispartofJournal of Microelectromechanical Systemsen_HK
dc.rightsIEEE Journal of Microelectromechanical Systems. Copyright © IEEE-
dc.rights©2012 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectContinuous glucose monitoringen_HK
dc.subjectinterstitial fluid (ISF)en_HK
dc.subjectmicrofluidic systemen_HK
dc.subjecttransdermal extractionen_HK
dc.titleAn interstitial fluid transdermal extraction system for continuous glucose monitoringen_HK
dc.typeArticleen_HK
dc.identifier.emailRoberts, RC: rcr8@hku.hken_HK
dc.identifier.emailTien, NC: nctien@hku.hken_HK
dc.identifier.authorityRoberts, RC=rp01738en_HK
dc.identifier.authorityTien, NC=rp01604en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1109/JMEMS.2012.2192910en_HK
dc.identifier.scopuseid_2-s2.0-84864594478en_HK
dc.identifier.hkuros222872-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864594478&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage917en_HK
dc.identifier.epage925en_HK
dc.identifier.isiWOS:000307124200021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYu, H=16240359300en_HK
dc.identifier.scopusauthoridLi, D=48761554400en_HK
dc.identifier.scopusauthoridRoberts, RC=24466830100en_HK
dc.identifier.scopusauthoridXu, K=7403282051en_HK
dc.identifier.scopusauthoridTien, NC=7006532826en_HK

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