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Article: Immunogrid: Towards agent-based simulations of the human immune system at a natural scale

TitleImmunogrid: Towards agent-based simulations of the human immune system at a natural scale
Authors
KeywordsAgent-Based Simulation
Grid Computing
Immunoinformatics
Systems Biology
Vaccine Discovery
Issue Date2010
PublisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1084
Citation
Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 2010, v. 368 n. 1920, p. 2799-2815 How to Cite?
AbstractThe ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model of the human immune system-that is, one that reflects both the diversity and the relative proportions of the molecules and cells that comprise it-together with the grid infrastructure necessary to apply this model to specific applications in the field of immunology. These objectives present the ImmunoGrid Consortium with formidable challenges in terms of complexity of the immune system, our partial understanding about how the immune system works, the lack of reliable data and the scale of computational resources required. In this paper, we explain the key challenges and the approaches adopted to overcome them. We also consider wider implications for the present ambitious plans to develop natural-scale, integrated models of the human body that can make contributions to personalized health care, such as the European Virtual Physiological Human initiative. Finally, we ask a key question: How long will it take us to resolve these challenges and when can we expect to have fully functional models that will deliver health-care benefits in the form of personalized care solutions and improved disease prevention? This journal is © 2010 The Royal Society.
Persistent Identifierhttp://hdl.handle.net/10722/175479
ISSN
2015 Impact Factor: 2.441
2015 SCImago Journal Rankings: 0.800
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHallingBrown, Men_US
dc.contributor.authorPappalardo, Fen_US
dc.contributor.authorRapin, Nen_US
dc.contributor.authorZhang, Pen_US
dc.contributor.authorAlemani, Den_US
dc.contributor.authorEmerson, Aen_US
dc.contributor.authorCastiglione, Fen_US
dc.contributor.authorDuroux, Pen_US
dc.contributor.authorPennisi, Men_US
dc.contributor.authorMiotto, Oen_US
dc.contributor.authorChurchill, Den_US
dc.contributor.authorRossi, Een_US
dc.contributor.authorMoss, DSen_US
dc.contributor.authorSansom, CEen_US
dc.contributor.authorBernaschi, Men_US
dc.contributor.authorLefranc, MPen_US
dc.contributor.authorBrunak, Sen_US
dc.contributor.authorLund, Oen_US
dc.contributor.authorMotta, Sen_US
dc.contributor.authorLollini, PLen_US
dc.contributor.authorMurgo, Aen_US
dc.contributor.authorPalladini, Aen_US
dc.contributor.authorBasford, KEen_US
dc.contributor.authorBrusic, Ven_US
dc.contributor.authorShepherd, AJen_US
dc.date.accessioned2012-11-26T08:58:55Z-
dc.date.available2012-11-26T08:58:55Z-
dc.date.issued2010en_US
dc.identifier.citationPhilosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 2010, v. 368 n. 1920, p. 2799-2815en_US
dc.identifier.issn1364-503Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175479-
dc.description.abstractThe ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model of the human immune system-that is, one that reflects both the diversity and the relative proportions of the molecules and cells that comprise it-together with the grid infrastructure necessary to apply this model to specific applications in the field of immunology. These objectives present the ImmunoGrid Consortium with formidable challenges in terms of complexity of the immune system, our partial understanding about how the immune system works, the lack of reliable data and the scale of computational resources required. In this paper, we explain the key challenges and the approaches adopted to overcome them. We also consider wider implications for the present ambitious plans to develop natural-scale, integrated models of the human body that can make contributions to personalized health care, such as the European Virtual Physiological Human initiative. Finally, we ask a key question: How long will it take us to resolve these challenges and when can we expect to have fully functional models that will deliver health-care benefits in the form of personalized care solutions and improved disease prevention? This journal is © 2010 The Royal Society.en_US
dc.languageengen_US
dc.publisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1084en_US
dc.relation.ispartofPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciencesen_US
dc.subjectAgent-Based Simulationen_US
dc.subjectGrid Computingen_US
dc.subjectImmunoinformaticsen_US
dc.subjectSystems Biologyen_US
dc.subjectVaccine Discoveryen_US
dc.titleImmunogrid: Towards agent-based simulations of the human immune system at a natural scaleen_US
dc.typeArticleen_US
dc.identifier.emailChurchill, D: dchurch@hku.hken_US
dc.identifier.authorityChurchill, D=rp00898en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1098/rsta.2010.0067en_US
dc.identifier.pmid20439274-
dc.identifier.scopuseid_2-s2.0-77953494820en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953494820&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume368en_US
dc.identifier.issue1920en_US
dc.identifier.spage2799en_US
dc.identifier.epage2815en_US
dc.identifier.isiWOS:000277207300012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHallingBrown, M=23094561900en_US
dc.identifier.scopusauthoridPappalardo, F=15020960900en_US
dc.identifier.scopusauthoridRapin, N=23390492100en_US
dc.identifier.scopusauthoridZhang, P=7404158718en_US
dc.identifier.scopusauthoridAlemani, D=8902177500en_US
dc.identifier.scopusauthoridEmerson, A=6603932475en_US
dc.identifier.scopusauthoridCastiglione, F=7004532366en_US
dc.identifier.scopusauthoridDuroux, P=12789537200en_US
dc.identifier.scopusauthoridPennisi, M=23091502800en_US
dc.identifier.scopusauthoridMiotto, O=8840256300en_US
dc.identifier.scopusauthoridChurchill, D=21233357300en_US
dc.identifier.scopusauthoridRossi, E=45662019300en_US
dc.identifier.scopusauthoridMoss, DS=7201847823en_US
dc.identifier.scopusauthoridSansom, CE=7005777188en_US
dc.identifier.scopusauthoridBernaschi, M=7004006883en_US
dc.identifier.scopusauthoridLefranc, MP=35462314500en_US
dc.identifier.scopusauthoridBrunak, S=7005477388en_US
dc.identifier.scopusauthoridLund, O=7103226268en_US
dc.identifier.scopusauthoridMotta, S=7005417927en_US
dc.identifier.scopusauthoridLollini, PL=35453610200en_US
dc.identifier.scopusauthoridMurgo, A=23009243200en_US
dc.identifier.scopusauthoridPalladini, A=8383489000en_US
dc.identifier.scopusauthoridBasford, KE=7003812245en_US
dc.identifier.scopusauthoridBrusic, V=7005279260en_US
dc.identifier.scopusauthoridShepherd, AJ=36118495000en_US
dc.identifier.citeulike7156972-

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