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Article: ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

TitleImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization
Authors
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://bib.oxfordjournals.org/
Citation
Briefings In Bioinformatics, 2009, v. 10 n. 3, p. 330-340 How to Cite?
AbstractVaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉. © The Author 2009. Published by Oxford University Press.
Persistent Identifierhttp://hdl.handle.net/10722/175459
ISSN
2015 Impact Factor: 8.399
2015 SCImago Journal Rankings: 4.086
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPappalardo, Fen_US
dc.contributor.authorHallingBrown, MDen_US
dc.contributor.authorRapin, Nen_US
dc.contributor.authorZhang, Pen_US
dc.contributor.authorAlemani, Den_US
dc.contributor.authorEmerson, Aen_US
dc.contributor.authorPaci, Pen_US
dc.contributor.authorDuroux, Pen_US
dc.contributor.authorPennisi, Men_US
dc.contributor.authorPalladini, Aen_US
dc.contributor.authorMiotto, Oen_US
dc.contributor.authorChurchill, Den_US
dc.contributor.authorRossi, Een_US
dc.contributor.authorShepherd, AJen_US
dc.contributor.authorMoss, DSen_US
dc.contributor.authorCastiglione, Fen_US
dc.contributor.authorBernaschi, Men_US
dc.contributor.authorLefranc, MPen_US
dc.contributor.authorBrunak, Sen_US
dc.contributor.authorMotta, Sen_US
dc.contributor.authorLollini, PLen_US
dc.contributor.authorBasford, KEen_US
dc.contributor.authorBrusic, Ven_US
dc.date.accessioned2012-11-26T08:58:50Z-
dc.date.available2012-11-26T08:58:50Z-
dc.date.issued2009en_US
dc.identifier.citationBriefings In Bioinformatics, 2009, v. 10 n. 3, p. 330-340en_US
dc.identifier.issn1467-5463en_US
dc.identifier.urihttp://hdl.handle.net/10722/175459-
dc.description.abstractVaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉. © The Author 2009. Published by Oxford University Press.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bib.oxfordjournals.org/en_US
dc.relation.ispartofBriefings in Bioinformaticsen_US
dc.subject.meshComputational Biology - Methodsen_US
dc.subject.meshComputer Systemsen_US
dc.subject.meshDatabase Management Systemsen_US
dc.subject.meshDatabases, Factualen_US
dc.subject.meshDrug Designen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune System - Physiologyen_US
dc.subject.meshMajor Histocompatibility Complexen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshSystems Integrationen_US
dc.subject.meshVaccinesen_US
dc.titleImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimizationen_US
dc.typeArticleen_US
dc.identifier.emailChurchill, D: dchurch@hku.hken_US
dc.identifier.authorityChurchill, D=rp00898en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/bib/bbp014en_US
dc.identifier.pmid19383844-
dc.identifier.scopuseid_2-s2.0-65549157113en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65549157113&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spage330en_US
dc.identifier.epage340en_US
dc.identifier.isiWOS:000265522200011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPappalardo, F=15020960900en_US
dc.identifier.scopusauthoridHallingBrown, MD=23094561900en_US
dc.identifier.scopusauthoridRapin, N=23390492100en_US
dc.identifier.scopusauthoridZhang, P=7404158718en_US
dc.identifier.scopusauthoridAlemani, D=8902177500en_US
dc.identifier.scopusauthoridEmerson, A=6603932475en_US
dc.identifier.scopusauthoridPaci, P=36890340300en_US
dc.identifier.scopusauthoridDuroux, P=12789537200en_US
dc.identifier.scopusauthoridPennisi, M=23091502800en_US
dc.identifier.scopusauthoridPalladini, A=8383489000en_US
dc.identifier.scopusauthoridMiotto, O=8840256300en_US
dc.identifier.scopusauthoridChurchill, D=21233357300en_US
dc.identifier.scopusauthoridRossi, E=45662019300en_US
dc.identifier.scopusauthoridShepherd, AJ=36118495000en_US
dc.identifier.scopusauthoridMoss, DS=7201847823en_US
dc.identifier.scopusauthoridCastiglione, F=7004532366en_US
dc.identifier.scopusauthoridBernaschi, M=7004006883en_US
dc.identifier.scopusauthoridLefranc, MP=35462314500en_US
dc.identifier.scopusauthoridBrunak, S=7005477388en_US
dc.identifier.scopusauthoridMotta, S=7005417927en_US
dc.identifier.scopusauthoridLollini, PL=35453610200en_US
dc.identifier.scopusauthoridBasford, KE=7003812245en_US
dc.identifier.scopusauthoridBrusic, V=7005279260en_US
dc.identifier.citeulike4373046-

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