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- Publisher Website: 10.1093/bib/bbp014
- Scopus: eid_2-s2.0-65549157113
- PMID: 19383844
- WOS: WOS:000265522200011
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Article: ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization
Title | ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization |
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Authors | |
Keywords | Computational modeling Grid computing Immunoinformatics Simulations Vaccine discovery |
Issue Date | 2009 |
Publisher | Oxford University Press. The Journal's web site is located at http://bib.oxfordjournals.org/ |
Citation | Briefings In Bioinformatics, 2009, v. 10 n. 3, p. 330-340 How to Cite? |
Abstract | Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉. © The Author 2009. Published by Oxford University Press. |
Persistent Identifier | http://hdl.handle.net/10722/175459 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 2.143 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Pappalardo, F | en_US |
dc.contributor.author | HallingBrown, MD | en_US |
dc.contributor.author | Rapin, N | en_US |
dc.contributor.author | Zhang, P | en_US |
dc.contributor.author | Alemani, D | en_US |
dc.contributor.author | Emerson, A | en_US |
dc.contributor.author | Paci, P | en_US |
dc.contributor.author | Duroux, P | en_US |
dc.contributor.author | Pennisi, M | en_US |
dc.contributor.author | Palladini, A | en_US |
dc.contributor.author | Miotto, O | en_US |
dc.contributor.author | Churchill, D | en_US |
dc.contributor.author | Rossi, E | en_US |
dc.contributor.author | Shepherd, AJ | en_US |
dc.contributor.author | Moss, DS | en_US |
dc.contributor.author | Castiglione, F | en_US |
dc.contributor.author | Bernaschi, M | en_US |
dc.contributor.author | Lefranc, MP | en_US |
dc.contributor.author | Brunak, S | en_US |
dc.contributor.author | Motta, S | en_US |
dc.contributor.author | Lollini, PL | en_US |
dc.contributor.author | Basford, KE | en_US |
dc.contributor.author | Brusic, V | en_US |
dc.date.accessioned | 2012-11-26T08:58:50Z | - |
dc.date.available | 2012-11-26T08:58:50Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Briefings In Bioinformatics, 2009, v. 10 n. 3, p. 330-340 | en_US |
dc.identifier.issn | 1467-5463 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175459 | - |
dc.description.abstract | Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉. © The Author 2009. Published by Oxford University Press. | en_US |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://bib.oxfordjournals.org/ | en_US |
dc.relation.ispartof | Briefings in Bioinformatics | en_US |
dc.subject | Computational modeling | - |
dc.subject | Grid computing | - |
dc.subject | Immunoinformatics | - |
dc.subject | Simulations | - |
dc.subject | Vaccine discovery | - |
dc.subject.mesh | Computational Biology - Methods | en_US |
dc.subject.mesh | Computer Systems | en_US |
dc.subject.mesh | Database Management Systems | en_US |
dc.subject.mesh | Databases, Factual | en_US |
dc.subject.mesh | Drug Design | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immune System - Physiology | en_US |
dc.subject.mesh | Major Histocompatibility Complex | en_US |
dc.subject.mesh | Models, Biological | en_US |
dc.subject.mesh | Systems Integration | en_US |
dc.subject.mesh | Vaccines | en_US |
dc.title | ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization | en_US |
dc.type | Article | en_US |
dc.identifier.email | Churchill, D: dchurch@hku.hk | en_US |
dc.identifier.authority | Churchill, D=rp00898 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/bib/bbp014 | en_US |
dc.identifier.pmid | 19383844 | - |
dc.identifier.scopus | eid_2-s2.0-65549157113 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-65549157113&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 330 | en_US |
dc.identifier.epage | 340 | en_US |
dc.identifier.isi | WOS:000265522200011 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Pappalardo, F=15020960900 | en_US |
dc.identifier.scopusauthorid | HallingBrown, MD=23094561900 | en_US |
dc.identifier.scopusauthorid | Rapin, N=23390492100 | en_US |
dc.identifier.scopusauthorid | Zhang, P=7404158718 | en_US |
dc.identifier.scopusauthorid | Alemani, D=8902177500 | en_US |
dc.identifier.scopusauthorid | Emerson, A=6603932475 | en_US |
dc.identifier.scopusauthorid | Paci, P=36890340300 | en_US |
dc.identifier.scopusauthorid | Duroux, P=12789537200 | en_US |
dc.identifier.scopusauthorid | Pennisi, M=23091502800 | en_US |
dc.identifier.scopusauthorid | Palladini, A=8383489000 | en_US |
dc.identifier.scopusauthorid | Miotto, O=8840256300 | en_US |
dc.identifier.scopusauthorid | Churchill, D=21233357300 | en_US |
dc.identifier.scopusauthorid | Rossi, E=45662019300 | en_US |
dc.identifier.scopusauthorid | Shepherd, AJ=36118495000 | en_US |
dc.identifier.scopusauthorid | Moss, DS=7201847823 | en_US |
dc.identifier.scopusauthorid | Castiglione, F=7004532366 | en_US |
dc.identifier.scopusauthorid | Bernaschi, M=7004006883 | en_US |
dc.identifier.scopusauthorid | Lefranc, MP=35462314500 | en_US |
dc.identifier.scopusauthorid | Brunak, S=7005477388 | en_US |
dc.identifier.scopusauthorid | Motta, S=7005417927 | en_US |
dc.identifier.scopusauthorid | Lollini, PL=35453610200 | en_US |
dc.identifier.scopusauthorid | Basford, KE=7003812245 | en_US |
dc.identifier.scopusauthorid | Brusic, V=7005279260 | en_US |
dc.identifier.citeulike | 4373046 | - |
dc.identifier.issnl | 1467-5463 | - |