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Article: Determination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatography
Title | Determination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatography |
---|---|
Authors | |
Keywords | Gradient Elution Related Substance Reversed-Phase High Performance Liquid Chromatography Ziprasidone Hydrochloride |
Issue Date | 2004 |
Publisher | Zhongguo Kexueyuan, Changchun Yingyong Huaxue Yanjiusuo. The Journal's web site is located at http://www.analchem.cn/ |
Citation | Fenxi Huaxue, 2004, v. 32 n. 7, p. 916-918 How to Cite? |
Abstract | A reversed-phase high performance liquid chromatographic method for analyzing ziprasidone hydrochloride and its related substances was established. The base-line separation of ziprasidone hydrochloride and 8 related substances was accomplished on a Diamonsil™ C18 (150 mm x 4.6 mm, 5 μm) column. Methanol was used as the mobile phase A, while acetate buffer at pH 6.0 was employed as mobile phase B. Gradient elution was adopted at the detection of 254 nm with a diode array detector. The limit of detection of each related substance can satisfy for quality control purpose. It is simple, reproducible and accurate. |
Persistent Identifier | http://hdl.handle.net/10722/175139 |
ISSN | 2023 Impact Factor: 1.2 2023 SCImago Journal Rankings: 0.355 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, N | en_US |
dc.contributor.author | Yu, Y | en_US |
dc.contributor.author | Shen, S | en_US |
dc.date.accessioned | 2012-11-26T08:49:23Z | - |
dc.date.available | 2012-11-26T08:49:23Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Fenxi Huaxue, 2004, v. 32 n. 7, p. 916-918 | en_US |
dc.identifier.issn | 0253-3820 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175139 | - |
dc.description.abstract | A reversed-phase high performance liquid chromatographic method for analyzing ziprasidone hydrochloride and its related substances was established. The base-line separation of ziprasidone hydrochloride and 8 related substances was accomplished on a Diamonsil™ C18 (150 mm x 4.6 mm, 5 μm) column. Methanol was used as the mobile phase A, while acetate buffer at pH 6.0 was employed as mobile phase B. Gradient elution was adopted at the detection of 254 nm with a diode array detector. The limit of detection of each related substance can satisfy for quality control purpose. It is simple, reproducible and accurate. | en_US |
dc.language | eng | en_US |
dc.publisher | Zhongguo Kexueyuan, Changchun Yingyong Huaxue Yanjiusuo. The Journal's web site is located at http://www.analchem.cn/ | en_US |
dc.relation.ispartof | Fenxi Huaxue | en_US |
dc.subject | Gradient Elution | en_US |
dc.subject | Related Substance | en_US |
dc.subject | Reversed-Phase High Performance Liquid Chromatography | en_US |
dc.subject | Ziprasidone Hydrochloride | en_US |
dc.title | Determination of ziprasidone hydrochloride and related substances by reversed-phase high performance liquid chromatography | en_US |
dc.type | Article | en_US |
dc.identifier.email | Shen, S: sshen@hkucc.hku.hk | en_US |
dc.identifier.authority | Shen, S=rp00775 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-4444332641 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4444332641&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 916 | en_US |
dc.identifier.epage | 918 | en_US |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Li, N=27170796800 | en_US |
dc.identifier.scopusauthorid | Yu, Y=8572872900 | en_US |
dc.identifier.scopusauthorid | Shen, S=7403431266 | en_US |
dc.identifier.issnl | 0253-3820 | - |