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Article: Rapid determination of tramadol in human plasma by headspace solid-phase microextraction and capillary gas chromatography-mass spectrometry

TitleRapid determination of tramadol in human plasma by headspace solid-phase microextraction and capillary gas chromatography-mass spectrometry
Authors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jpba
Citation
Journal Of Pharmaceutical And Biomedical Analysis, 2005, v. 37 n. 1, p. 143-147 How to Cite?
AbstractA simple, rapid and sensitive method for determination of tramadol in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC-MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-μm polydimethylsiloxane/divinylbenzene (PDMS/DVB) fiber; 0.5 mL of plasma modified with 0.5 mL of sodium hydroxide (0.1 M); extraction temperature of 100°C, with stirring at 2000 rpm for 30 min. The calibration curve showed linearity in the range of 1-400 ng mL-1 with regression coefficient corresponding to 0.9986 and coefficient of the variation of the points of the calibration curve lower than 10%. The detection limit for tramadol in plasma was 0.2 ng mL-1. The proposed method was successfully applied to determination of tramadol in human plasma samples from 10 healthy volunteers after a single oral administration. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/174928
ISSN
2015 Impact Factor: 3.169
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSha, YFen_US
dc.contributor.authorShen, Sen_US
dc.contributor.authorDuan, GLen_US
dc.date.accessioned2012-11-26T08:48:12Z-
dc.date.available2012-11-26T08:48:12Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Pharmaceutical And Biomedical Analysis, 2005, v. 37 n. 1, p. 143-147en_US
dc.identifier.issn0731-7085en_US
dc.identifier.urihttp://hdl.handle.net/10722/174928-
dc.description.abstractA simple, rapid and sensitive method for determination of tramadol in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC-MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-μm polydimethylsiloxane/divinylbenzene (PDMS/DVB) fiber; 0.5 mL of plasma modified with 0.5 mL of sodium hydroxide (0.1 M); extraction temperature of 100°C, with stirring at 2000 rpm for 30 min. The calibration curve showed linearity in the range of 1-400 ng mL-1 with regression coefficient corresponding to 0.9986 and coefficient of the variation of the points of the calibration curve lower than 10%. The detection limit for tramadol in plasma was 0.2 ng mL-1. The proposed method was successfully applied to determination of tramadol in human plasma samples from 10 healthy volunteers after a single oral administration. © 2004 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jpbaen_US
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysisen_US
dc.subject.meshElectrophoresis, Capillary - Methodsen_US
dc.subject.meshGas Chromatography-Mass Spectrometry - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTramadol - Blood - Chemistryen_US
dc.titleRapid determination of tramadol in human plasma by headspace solid-phase microextraction and capillary gas chromatography-mass spectrometryen_US
dc.typeArticleen_US
dc.identifier.emailShen, S: sshen@hkucc.hku.hken_US
dc.identifier.authorityShen, S=rp00775en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jpba.2004.09.050en_US
dc.identifier.pmid15664754-
dc.identifier.scopuseid_2-s2.0-12344335164en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344335164&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue1en_US
dc.identifier.spage143en_US
dc.identifier.epage147en_US
dc.identifier.isiWOS:000227014200017-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSha, YF=7102250309en_US
dc.identifier.scopusauthoridShen, S=7403431266en_US
dc.identifier.scopusauthoridDuan, GL=7101615513en_US

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