Postgraduate Thesis: Subphenotype stratification in systemic lupus erythematosus

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TitleSubphenotype stratification in systemic lupus erythematosus
AuthorsLi, Hei, Philip.
李曦.
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
AbstractSubsets of systemic lupus erythematosus (SLE) patients with distinct patterns of disease manifestations and autoantibody production have been reported, but seldom have these two phenomena been analysed together. Cluster analysis was performed on 1928 Chinese SLE patients based on autoantibody profile and the frequencies of various clinical manifestations were compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations, as well as between clinical manifestations, were also performed. This study identifies three separate autoantibody clusters each with different clinical manifestations, and proposes that the phenomena of autoantibody clustering and clinical subsets may be inter-related. Patient clusters could also be stratified into a bipolar spectrum. On one end are patients with over-representation of anti-dsDNA and renal disorder; whilst on the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and aPL/anti-Ro/anti-La) with overlapping of other non-renal manifestations. Patient stratification could aid disease prediction and subsequent management. These findings may also elucidate disease pathogenesis and guide future study on potential common pathological processes within autoantibody clusters.
DegreeMaster of Research in Medicine
SubjectSystemic lupus erythematosus - Immunological aspects.
autoantibody clusters
Dept/ProgramPaediatrics and Adolescent Medicine
DC Field
Value
dc.contributor.authorLi, Hei, Philip.
dc.contributor.author李曦.
dc.date.hkucongregation2012
dc.date.issued2012
dc.description.abstractSubsets of systemic lupus erythematosus (SLE) patients with distinct patterns of disease manifestations and autoantibody production have been reported, but seldom have these two phenomena been analysed together. Cluster analysis was performed on 1928 Chinese SLE patients based on autoantibody profile and the frequencies of various clinical manifestations were compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations, as well as between clinical manifestations, were also performed. This study identifies three separate autoantibody clusters each with different clinical manifestations, and proposes that the phenomena of autoantibody clustering and clinical subsets may be inter-related. Patient clusters could also be stratified into a bipolar spectrum. On one end are patients with over-representation of anti-dsDNA and renal disorder; whilst on the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and aPL/anti-Ro/anti-La) with overlapping of other non-renal manifestations. Patient stratification could aid disease prediction and subsequent management. These findings may also elucidate disease pathogenesis and guide future study on potential common pathological processes within autoantibody clusters.
dc.description.naturepublished_or_final_version
dc.description.thesisdisciplinePaediatrics and Adolescent Medicine
dc.description.thesislevelmaster's
dc.description.thesisnameMaster of Research in Medicine
dc.identifier.hkulb4833476
dc.languageeng
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
dc.relation.ispartofHKU Theses Online (HKUTO)
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.source.urihttp://hub.hku.hk/bib/B48334765
dc.subject.lcshSystemic lupus erythematosus - Immunological aspects.
dc.subject.lcshautoantibody clusters
dc.titleSubphenotype stratification in systemic lupus erythematosus
dc.typePG_Thesis