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Article: Clinical correlates of functional performance in community-dwelling Chinese older persons with mild cognitive impairment

TitleClinical correlates of functional performance in community-dwelling Chinese older persons with mild cognitive impairment
Authors
Issue Date2008
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=IPG
Citation
International Psychogeriatrics, 2008, v. 20 n. 5, p. 1059-1070 How to Cite?
AbstractBackground: Increasing evidence suggests that functional impairment can be detected in older persons with mild cognitive impairment (MCI). This study explores the functional profiles and the clinical correlates of a population-based sample of Chinese older persons with MCI in Hong Kong. Methods: A random sample of 765 Chinese elderly subjects without dementia was recruited, of which 389 were elderly normal controls (Clinical Dementia Rating = 0), and 376 had questionable dementia (CDR = 0.5). The latter were categorized into an MCI group (n = 291) and a very mild dementia (VMD) group (n = 85). Their functional performances were measured and compared with the normal controls (NC). Multiple regression analyses investigated the associations between functional scores (Disability Assessment in Dementia) and clinical correlates (cognitive test scores, neuropsychiatric symptoms and motor signs) in the NC subjects and cognitively impaired subjects. Results: Subjects with MCI had intermediate functional performance between the NC and those with VMD. Regression analyses revealed that lower scores of cognitive tests (delayed recall and categorical verbal fluency tests), apathy, aberrant motor symptoms and parkinsonism features were associated with lower functional scores in clinically non-demented subjects. Functional scores had no correlation with age, education and medical illness burden. Conclusion: Neuropsychiatric symptoms and parkinsonism features were associated with functional impairment in the clinically non-demented elderly in the community. Assessment of these should be incorporated in the evaluation of older persons for early cognitive impairment. © 2008 International Psychogeriatric Association.
Persistent Identifierhttp://hdl.handle.net/10722/174243
ISSN
2015 Impact Factor: 2.22
2015 SCImago Journal Rankings: 1.068
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTam, CWCen_US
dc.contributor.authorLam, LCWen_US
dc.contributor.authorLui, VWCen_US
dc.contributor.authorChan, WCen_US
dc.contributor.authorChan, SSMen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorChan, WMen_US
dc.date.accessioned2012-11-22T02:01:32Z-
dc.date.available2012-11-22T02:01:32Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Psychogeriatrics, 2008, v. 20 n. 5, p. 1059-1070en_US
dc.identifier.issn1041-6102en_US
dc.identifier.urihttp://hdl.handle.net/10722/174243-
dc.description.abstractBackground: Increasing evidence suggests that functional impairment can be detected in older persons with mild cognitive impairment (MCI). This study explores the functional profiles and the clinical correlates of a population-based sample of Chinese older persons with MCI in Hong Kong. Methods: A random sample of 765 Chinese elderly subjects without dementia was recruited, of which 389 were elderly normal controls (Clinical Dementia Rating = 0), and 376 had questionable dementia (CDR = 0.5). The latter were categorized into an MCI group (n = 291) and a very mild dementia (VMD) group (n = 85). Their functional performances were measured and compared with the normal controls (NC). Multiple regression analyses investigated the associations between functional scores (Disability Assessment in Dementia) and clinical correlates (cognitive test scores, neuropsychiatric symptoms and motor signs) in the NC subjects and cognitively impaired subjects. Results: Subjects with MCI had intermediate functional performance between the NC and those with VMD. Regression analyses revealed that lower scores of cognitive tests (delayed recall and categorical verbal fluency tests), apathy, aberrant motor symptoms and parkinsonism features were associated with lower functional scores in clinically non-demented subjects. Functional scores had no correlation with age, education and medical illness burden. Conclusion: Neuropsychiatric symptoms and parkinsonism features were associated with functional impairment in the clinically non-demented elderly in the community. Assessment of these should be incorporated in the evaluation of older persons for early cognitive impairment. © 2008 International Psychogeriatric Association.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=IPGen_US
dc.relation.ispartofInternational Psychogeriatricsen_US
dc.subject.meshActivities Of Daily Living - Classification - Psychologyen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAged - Statistics & Numerical Dataen_US
dc.subject.meshAsian Continental Ancestry Group - Psychology - Statistics & Numerical Dataen_US
dc.subject.meshCognition Disorders - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshControl Groupsen_US
dc.subject.meshData Collection - Statistics & Numerical Dataen_US
dc.subject.meshDementia - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshDisability Evaluationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGeriatric Assessment - Statistics & Numerical Dataen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuropsychological Tests - Statistics & Numerical Dataen_US
dc.subject.meshParkinsonian Disorders - Diagnosis - Psychologyen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSampling Studiesen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.titleClinical correlates of functional performance in community-dwelling Chinese older persons with mild cognitive impairmenten_US
dc.typeArticleen_US
dc.identifier.emailChan, WC: waicchan@hku.hken_US
dc.identifier.authorityChan, WC=rp01687en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S1041610208007345en_US
dc.identifier.pmid18498668-
dc.identifier.scopuseid_2-s2.0-50149108220en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50149108220&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue5en_US
dc.identifier.spage1059en_US
dc.identifier.epage1070en_US
dc.identifier.isiWOS:000259356300017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTam, CWC=26021559000en_US
dc.identifier.scopusauthoridLam, LCW=7201984627en_US
dc.identifier.scopusauthoridLui, VWC=9245605300en_US
dc.identifier.scopusauthoridChan, WC=16400525900en_US
dc.identifier.scopusauthoridChan, SSM=13409371900en_US
dc.identifier.scopusauthoridChiu, HFK=7401986628en_US
dc.identifier.scopusauthoridChan, WM=7403918361en_US

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