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Article: Trajectories of quality of life among Chinese patients diagnosed with nasopharynegeal cancer

TitleTrajectories of quality of life among Chinese patients diagnosed with nasopharynegeal cancer
Authors
KeywordsAge
Appetite
Gender
Income
Longitudinal study
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 9, article no. e44022 How to Cite?
AbstractOBJECTIVE: This secondary longitudinal analysis describes distinct quality of life trajectories during eight months of radiation therapy (RT) among patients with nasopharyngeal cancer (NPC) and examines factors differentiating these trajectories. METHODS: 253 Chinese patients with NPC scheduled for RT were assessed at pre-treatment, and 4 months and 8 months later on QoL (Chinese version of the FACT-G), optimism, pain, eating function, and patient satisfaction. Latent growth mixture modelling identified different trajectories within each of four QoL domains: Physical, Emotional, Social/family, and Functional well-being. Multinomial logistic regression compared optimism, pain, eating function, and patient satisfaction by trajectories adjusted for demographic and medical characteristics. RESULTS: We identified three distinct trajectories for physical and emotional QoL domains, four trajectories for social/family, and two trajectories for functional domains. Within each domain most patients (physical (77%), emotional (85%), social/family (55%) and functional (63%)) experienced relatively stable high levels of well-being over the 8-month period. Different Physical trajectory patterns were predicted by pain and optimism, whereas for Emotion-domain trajectories pain, optimism, eating enjoyment, patient satisfaction with information, and gender were predictive. Age, appetite, optimism, martial status, and household income predicted Social/family trajectories; household income, eating enjoyment, optimism, and patient satisfaction with information predicted Functional trajectories. CONCLUSION: Most patients with NPC showed high stable QoL during radiotherapy. Optimism predicted good QoL. Symptom impacts varied by QoL domain. Information satisfaction was protective in emotional and functional well-being, reflecting the importance in helping patients to establish a realistic expectation of treatment impacts.
Persistent Identifierhttp://hdl.handle.net/10722/174164
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, WWTen_US
dc.contributor.authorYe, Men_US
dc.contributor.authorFielding, Ren_US
dc.date.accessioned2012-11-16T03:37:40Z-
dc.date.available2012-11-16T03:37:40Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 9, article no. e44022en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/174164-
dc.description.abstractOBJECTIVE: This secondary longitudinal analysis describes distinct quality of life trajectories during eight months of radiation therapy (RT) among patients with nasopharyngeal cancer (NPC) and examines factors differentiating these trajectories. METHODS: 253 Chinese patients with NPC scheduled for RT were assessed at pre-treatment, and 4 months and 8 months later on QoL (Chinese version of the FACT-G), optimism, pain, eating function, and patient satisfaction. Latent growth mixture modelling identified different trajectories within each of four QoL domains: Physical, Emotional, Social/family, and Functional well-being. Multinomial logistic regression compared optimism, pain, eating function, and patient satisfaction by trajectories adjusted for demographic and medical characteristics. RESULTS: We identified three distinct trajectories for physical and emotional QoL domains, four trajectories for social/family, and two trajectories for functional domains. Within each domain most patients (physical (77%), emotional (85%), social/family (55%) and functional (63%)) experienced relatively stable high levels of well-being over the 8-month period. Different Physical trajectory patterns were predicted by pain and optimism, whereas for Emotion-domain trajectories pain, optimism, eating enjoyment, patient satisfaction with information, and gender were predictive. Age, appetite, optimism, martial status, and household income predicted Social/family trajectories; household income, eating enjoyment, optimism, and patient satisfaction with information predicted Functional trajectories. CONCLUSION: Most patients with NPC showed high stable QoL during radiotherapy. Optimism predicted good QoL. Symptom impacts varied by QoL domain. Information satisfaction was protective in emotional and functional well-being, reflecting the importance in helping patients to establish a realistic expectation of treatment impacts.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAge-
dc.subjectAppetite-
dc.subjectGender-
dc.subjectIncome-
dc.subjectLongitudinal study-
dc.titleTrajectories of quality of life among Chinese patients diagnosed with nasopharynegeal canceren_US
dc.typeArticleen_US
dc.identifier.emailLam, WWT: wwtlam@hku.hken_US
dc.identifier.emailYe, M: miye@hku.hken_US
dc.identifier.emailFielding, R: fielding@hku.hken_US
dc.identifier.authorityLam, WWT=rp00443en_US
dc.identifier.authorityFielding, R=rp00339en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0044022-
dc.identifier.pmid23028484-
dc.identifier.pmcidPMC3445583-
dc.identifier.scopuseid_2-s2.0-84866519212-
dc.identifier.hkuros212294en_US
dc.identifier.volume7en_US
dc.identifier.issue9, article no. e44022en_US
dc.identifier.isiWOS:000311313900012-
dc.publisher.placeUnited States-

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