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Article: Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination

TitleAntibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination
Authors
KeywordsAmbient illumination
Anti-bacterial activity
ATR FTIR
Cell walls
Functionalized nanoparticles
Issue Date2012
PublisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/nano
Citation
Nanotechnology, 2012, v. 23 n. 47 How to Cite?
AbstractIn various practical applications, nanomaterials typically have functionalized surfaces. Yet, the studies of toxicity and antibacterial activity of functionalized nanoparticles are scarce. We investigated the effect of surface modifications on antibacterial activity of ZnO under ambient illumination, and we found that nanoparticles coated with different surface modifying reagents could exhibit higher or lower toxicity compared to bare ZnO, depending on the surface modifying reagent used. Different surface modifying reagent molecules resulted in differences in the release of Zn 2+ ions and the production of reactive oxygen species (ROS). However, the antibacterial activity did not correlate with the ROS levels or the Zn 2+ ion release. One of the surface-modified ZnO samples exhibited significantly lower Zn 2+ ion release while at the same time exhibiting improved antibacterial activity. In all cases, damage of the cell wall membranes and/or changes in the membrane permeability have been observed, together with the changes in ATR-FTIR spectra indicating differences in protein conformation. Mechanisms of antibacterial activity are discussed. © 2012 IOP Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/174113
ISSN
2015 Impact Factor: 3.573
2015 SCImago Journal Rankings: 1.196
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, YHen_HK
dc.contributor.authorChan, CMNen_HK
dc.contributor.authorNg, AMCen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorChiang, MWLen_HK
dc.contributor.authorDjurišić, ABen_HK
dc.contributor.authorNg, YHen_HK
dc.contributor.authorJim, WYen_HK
dc.contributor.authorGuo, MYen_HK
dc.contributor.authorLeung, FCCen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorAu, DTWen_HK
dc.date.accessioned2012-11-16T03:34:41Z-
dc.date.available2012-11-16T03:34:41Z-
dc.date.issued2012en_HK
dc.identifier.citationNanotechnology, 2012, v. 23 n. 47en_HK
dc.identifier.issn0957-4484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/174113-
dc.description.abstractIn various practical applications, nanomaterials typically have functionalized surfaces. Yet, the studies of toxicity and antibacterial activity of functionalized nanoparticles are scarce. We investigated the effect of surface modifications on antibacterial activity of ZnO under ambient illumination, and we found that nanoparticles coated with different surface modifying reagents could exhibit higher or lower toxicity compared to bare ZnO, depending on the surface modifying reagent used. Different surface modifying reagent molecules resulted in differences in the release of Zn 2+ ions and the production of reactive oxygen species (ROS). However, the antibacterial activity did not correlate with the ROS levels or the Zn 2+ ion release. One of the surface-modified ZnO samples exhibited significantly lower Zn 2+ ion release while at the same time exhibiting improved antibacterial activity. In all cases, damage of the cell wall membranes and/or changes in the membrane permeability have been observed, together with the changes in ATR-FTIR spectra indicating differences in protein conformation. Mechanisms of antibacterial activity are discussed. © 2012 IOP Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/nanoen_HK
dc.relation.ispartofNanotechnologyen_HK
dc.rightsNanotechnology. Copyright © Institute of Physics Publishing.-
dc.subjectAmbient illumination-
dc.subjectAnti-bacterial activity-
dc.subjectATR FTIR-
dc.subjectCell walls-
dc.subjectFunctionalized nanoparticles-
dc.titleAntibacterial activity of ZnO nanoparticles with a modified surface under ambient illuminationen_HK
dc.typeArticleen_HK
dc.identifier.emailDjurišić, AB: dalek@hku.hken_HK
dc.identifier.emailChan, WK: waichan@hku.hken_HK
dc.identifier.authorityDjurišić, AB=rp00690en_HK
dc.identifier.authorityChan, WK=rp00667en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1088/0957-4484/23/47/475703en_HK
dc.identifier.pmid23103840en_HK
dc.identifier.scopuseid_2-s2.0-84868118731en_HK
dc.identifier.hkuros212291en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84868118731&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue47en_HK
dc.identifier.isiWOS:000310856100017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, YH=55440652500en_HK
dc.identifier.scopusauthoridChan, CMN=35239877600en_HK
dc.identifier.scopusauthoridNg, AMC=12140078600en_HK
dc.identifier.scopusauthoridChan, HT=55232512300en_HK
dc.identifier.scopusauthoridChiang, MWL=55441635300en_HK
dc.identifier.scopusauthoridDjurišić, AB=7004904830en_HK
dc.identifier.scopusauthoridNg, YH=55154006100en_HK
dc.identifier.scopusauthoridJim, WY=55441124600en_HK
dc.identifier.scopusauthoridGuo, MY=41761700900en_HK
dc.identifier.scopusauthoridLeung, FCC=55440652400en_HK
dc.identifier.scopusauthoridChan, WK=13310083000en_HK
dc.identifier.scopusauthoridAu, DTW=35239719800en_HK

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