Use Of Cytoplasmic C-Myc For Regulating Immune Responses

Abstract

The Subject Invention Provides Novel Uses Of Cytoplasmic C-Myc For Modulation Of Innate Immune Responses. The Invention Is Based, At Least In Part, On The Surprising Discovery That Cytoplasmic C-Myc, Instead Of Nuclear C-Myc, Modulates Pro-Inflammatory Immune Responses Via Its Role As A Positive Feedback Regulator. Specifically, The Subject Invention Provides Methods For Treatment Or Amelioration Of Inflammatory Diseases And/Or Immune Disorders Via Inhibition C-Myc Expression Or Its Activity. Also Provided Are Methods For The Development Of Therapeutic Agents For Treating Infection, Inflammation, Immune Diseases And Autoimmune Diseases.