Soluble Pd-1 Variants, Fusion Constructs, And Uses Thereof

Abstract

The Subject Invention Provides Novel Soluble Pd-1 (Spd-1) Proteins, Nucleic Acids, And Fusion Constructs Thereof, For Enhancing Humoral And Cell-Mediated Immunity Of A Subject. Also Provided Are Therapeutic Compositions Comprising The Spd-1 Proteins, Nucleic Acids, And Fusion Constructs Of The Subject Invention. In A Preferred Embodiment, The Therapeutic Composition Is Formulated As A Vaccine Composition. Advantageously, The Spd-1 Proteins, Nucleic Acids, And Therapeutic Compositions Provide Protective Immunity Against Pathogenic Infection Including Hiv Infection. In Additon, The Subject Invention Can Be Used In The Prevention And/Or Treatment Of Tumor Or Cancer.