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postgraduate thesis: A comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci

TitleA comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci
Authors
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Abstract
Background NVS is a fastidious group of streptococci that can give rise to serious invasive infections in humans. Apart from endocarditis, clinical features of this group of pathogens have not been compared with other more commonly encountered streptococci Purpose of study The demographics, clinical features and outcome of patients with nutritionally variant streptococci infection were compared with a concurrent cohort of patients with viridans streptococci infection Study design. The clinical and microbiological data of hospitalized adult patients from year 2002 to 2011 infected with nutritionally variant streptococci or viridans streptococci were analysed. Results A total of 241 patients including 21 NVS and 220 viridans streptococci were analysed. The mean age of NVS patients was lower than viridans streptococci (54.7 vs 63.9, p = 0.042). When compared with 63 age and sex matched viridans streptococci controls, significantly more NVS patients have hematological malignancy (p=0.007) and had fever at the time of presentation (p=0.012). They are more common to have bone and joint infection (p=0.032), line sepsis (p=0.013) and primary bacteremia (p=0.039). Most isolates of NVS were from blood culture specimens (p=0.002). There were no statistical significance in terms of 30-day mortality and length of hospital stay between the two groups. Conclusion NVS tends to infect slightly younger patients, patients with hematological malignancy and cause more bacteremia than viridans streptococci. It is important not to discard positive blood culture isolate with NVS as contaminant.
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
DegreePostgraduate Diploma in Infectious Diseases
SubjectStreptococcus.
Dept/ProgramMicrobiology
Persistent Identifierhttp://hdl.handle.net/10722/173737

 

DC FieldValueLanguage
dc.contributor.authorLui, Leoen_HK
dc.contributor.author呂志侯zh_HK
dc.date.accessioned2012-11-01T02:50:32Z-
dc.date.available2012-11-01T02:50:32Z-
dc.date.issued2012en_US
dc.identifier.urihttp://hdl.handle.net/10722/173737-
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.en_US
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."en_US
dc.descriptionIncludes bibliographical references (p. 28-32).en_US
dc.description.abstractBackground NVS is a fastidious group of streptococci that can give rise to serious invasive infections in humans. Apart from endocarditis, clinical features of this group of pathogens have not been compared with other more commonly encountered streptococci Purpose of study The demographics, clinical features and outcome of patients with nutritionally variant streptococci infection were compared with a concurrent cohort of patients with viridans streptococci infection Study design. The clinical and microbiological data of hospitalized adult patients from year 2002 to 2011 infected with nutritionally variant streptococci or viridans streptococci were analysed. Results A total of 241 patients including 21 NVS and 220 viridans streptococci were analysed. The mean age of NVS patients was lower than viridans streptococci (54.7 vs 63.9, p = 0.042). When compared with 63 age and sex matched viridans streptococci controls, significantly more NVS patients have hematological malignancy (p=0.007) and had fever at the time of presentation (p=0.012). They are more common to have bone and joint infection (p=0.032), line sepsis (p=0.013) and primary bacteremia (p=0.039). Most isolates of NVS were from blood culture specimens (p=0.002). There were no statistical significance in terms of 30-day mortality and length of hospital stay between the two groups. Conclusion NVS tends to infect slightly younger patients, patients with hematological malignancy and cause more bacteremia than viridans streptococci. It is important not to discard positive blood culture isolate with NVS as contaminant.en_US
dc.languageengen_US
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.en_US
dc.subject.lcshStreptococcus.en_US
dc.titleA comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococcien_HK
dc.typePG_Thesisen_US
dc.identifier.hkulb4832045en_US
dc.description.thesisnamePostgraduate Diploma in Infectious Diseasesen_US
dc.description.thesislevelPostgraduate diplomaen_US
dc.description.thesisdisciplineMicrobiologyen_US
dc.description.naturepublished_or_final_versionen_US

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