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Postgraduate Thesis: A comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci
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TitleA comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci
 
AuthorsLui, Leo
呂志侯
 
Issue Date2012
 
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
AbstractBackground NVS is a fastidious group of streptococci that can give rise to serious invasive infections in humans. Apart from endocarditis, clinical features of this group of pathogens have not been compared with other more commonly encountered streptococci Purpose of study The demographics, clinical features and outcome of patients with nutritionally variant streptococci infection were compared with a concurrent cohort of patients with viridans streptococci infection Study design. The clinical and microbiological data of hospitalized adult patients from year 2002 to 2011 infected with nutritionally variant streptococci or viridans streptococci were analysed. Results A total of 241 patients including 21 NVS and 220 viridans streptococci were analysed. The mean age of NVS patients was lower than viridans streptococci (54.7 vs 63.9, p = 0.042). When compared with 63 age and sex matched viridans streptococci controls, significantly more NVS patients have hematological malignancy (p=0.007) and had fever at the time of presentation (p=0.012). They are more common to have bone and joint infection (p=0.032), line sepsis (p=0.013) and primary bacteremia (p=0.039). Most isolates of NVS were from blood culture specimens (p=0.002). There were no statistical significance in terms of 30-day mortality and length of hospital stay between the two groups. Conclusion NVS tends to infect slightly younger patients, patients with hematological malignancy and cause more bacteremia than viridans streptococci. It is important not to discard positive blood culture isolate with NVS as contaminant.
 
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references (p. 28-32).
 
DegreePostgraduate Diploma in Infectious Diseases
 
SubjectStreptococcus.
 
Dept/ProgramMicrobiology
 
DC FieldValue
dc.contributor.authorLui, Leo
 
dc.contributor.author呂志侯
 
dc.date.accessioned2012-11-01T02:50:32Z
 
dc.date.available2012-11-01T02:50:32Z
 
dc.date.issued2012
 
dc.description.abstractBackground NVS is a fastidious group of streptococci that can give rise to serious invasive infections in humans. Apart from endocarditis, clinical features of this group of pathogens have not been compared with other more commonly encountered streptococci Purpose of study The demographics, clinical features and outcome of patients with nutritionally variant streptococci infection were compared with a concurrent cohort of patients with viridans streptococci infection Study design. The clinical and microbiological data of hospitalized adult patients from year 2002 to 2011 infected with nutritionally variant streptococci or viridans streptococci were analysed. Results A total of 241 patients including 21 NVS and 220 viridans streptococci were analysed. The mean age of NVS patients was lower than viridans streptococci (54.7 vs 63.9, p = 0.042). When compared with 63 age and sex matched viridans streptococci controls, significantly more NVS patients have hematological malignancy (p=0.007) and had fever at the time of presentation (p=0.012). They are more common to have bone and joint infection (p=0.032), line sepsis (p=0.013) and primary bacteremia (p=0.039). Most isolates of NVS were from blood culture specimens (p=0.002). There were no statistical significance in terms of 30-day mortality and length of hospital stay between the two groups. Conclusion NVS tends to infect slightly younger patients, patients with hematological malignancy and cause more bacteremia than viridans streptococci. It is important not to discard positive blood culture isolate with NVS as contaminant.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.
 
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
 
dc.descriptionIncludes bibliographical references (p. 28-32).
 
dc.description.thesisdisciplineMicrobiology
 
dc.description.thesislevelPostgraduate diploma
 
dc.description.thesisnamePostgraduate Diploma in Infectious Diseases
 
dc.identifier.hkulb4832045
 
dc.identifier.urihttp://hdl.handle.net/10722/173737
 
dc.languageeng
 
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
 
dc.subject.lcshStreptococcus.
 
dc.titleA comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci
 
dc.typePG_Thesis
 
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<item><contributor.author>Lui, Leo</contributor.author>
<contributor.author>&#21570;&#24535;&#20399;</contributor.author>
<date.accessioned>2012-11-01T02:50:32Z</date.accessioned>
<date.available>2012-11-01T02:50:32Z</date.available>
<date.issued>2012</date.issued>
<identifier.uri>http://hdl.handle.net/10722/173737</identifier.uri>
<description>Thesis (P. Dip.)--University of Hong Kong, 2012.</description>
<description>&quot;This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK).&quot;</description>
<description>Includes bibliographical references (p. 28-32).</description>
<description.abstract>Background NVS is a fastidious group of streptococci that can give rise to serious
invasive infections in humans. Apart from endocarditis, clinical features of this
group of pathogens have not been compared with other more commonly
encountered streptococci
Purpose of study The demographics, clinical features and outcome of patients
with nutritionally variant streptococci infection were compared with a concurrent
cohort of patients with viridans streptococci infection
Study design. The clinical and microbiological data of hospitalized adult patients
from year 2002 to 2011 infected with nutritionally variant streptococci or viridans
streptococci were analysed.
Results A total of 241 patients including 21 NVS and 220 viridans streptococci were
analysed. The mean age of NVS patients was lower than viridans streptococci
(54.7 vs 63.9, p = 0.042). When compared with 63 age and sex matched viridans
streptococci controls, significantly more NVS patients have hematological
malignancy (p=0.007) and had fever at the time of presentation (p=0.012). They
are more common to have bone and joint infection (p=0.032), line sepsis (p=0.013)
and primary bacteremia (p=0.039). Most isolates of NVS were from blood culture
specimens (p=0.002). There were no statistical significance in terms of 30-day
mortality and length of hospital stay between the two groups.
Conclusion NVS tends to infect slightly younger patients, patients with
hematological malignancy and cause more bacteremia than viridans streptococci.
It is important not to discard positive blood culture isolate with NVS as contaminant.</description.abstract>
<language>eng</language>
<publisher>The University of Hong Kong (Pokfulam, Hong Kong)</publisher>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The author retains all proprietary rights, (such as patent rights) and the right to use in future works.</rights>
<subject.lcsh>Streptococcus.</subject.lcsh>
<title>A comparison of clinical characteristics between nutritionally variant streptococci (NVS) and viridans streptococci</title>
<type>PG_Thesis</type>
<identifier.hkul>b4832045</identifier.hkul>
<description.thesisname>Postgraduate Diploma in Infectious Diseases</description.thesisname>
<description.thesislevel>Postgraduate diploma</description.thesislevel>
<description.thesisdiscipline>Microbiology</description.thesisdiscipline>
<description.nature>published_or_final_version</description.nature>
<bitstream.url>http://hub.hku.hk/bitstream/10722/173737/1/FullText.pdf</bitstream.url>
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