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postgraduate thesis: A retrospective descriptive study on pulmonary tuberculosis patients in ICU

TitleA retrospective descriptive study on pulmonary tuberculosis patients in ICU
Authors
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
AbstractBackground Mycobacterium tuberculosis (MTB) is an endemic disease in Hong Kong. The annual notification rate was 74.2 per 100, 000 population (1) compared with 3.8 per 100,000 population in the United States in 2009 (2). The reported hospital mortality of MTB admitted to intensive care unit (ICU) was 67-81% (3). This study aims at reviewing the characteristics and outcomes of pulmonary tuberculosis patients admitted to ICU in a local tertiary hospital. Objective To describe the demographic data, all-cause mortality, rate of developing concomitant bacterial infection, anti-tuberculosis drugs prescription pattern and the rate of drug induced side effects such as hepatotoxicity in patients with tuberculosis admitted to ICU. Design Retrospective descriptive study conducted in a mixed surgical and medical ICU in Hong Kong. Patients were critically ill patients diagnosed to have active MTB from January 2004 to December 2009. Results Eighty five patients were identified with active MTB in the study period. The mean age was 55.1±1.7 years old. Twenty six (30.6%) of the patients were above 65 years old. Seventy one (83.5%) of the patients were male. Twenty one (24.7%) of the patients had history of tuberculosis. Thirty two (37.7%) of the patients presented with fever for more than 1 week; 35 patients (41.2%) presented with subjective weight lost and 60% admitted to ICU due to respiratory failure. Sixty nine (81.2%) of the patients were intubated. Fifty seven (67.1%) of the patients had at least four types of anti-TB drugs started during hospitalization. Sixty (70%) of the patients had both isoniazid and rifampicin included in their anti-TB regimen. Eleven (16.7%) of the patients receiving anti-TB treatment were complicated with drug-induced hepatotoxicity. Thirteen (15.3%) patients were diagnosed by physicians to have hospital acquired pneumonia during ICU stay. The ICU all-cause mortality was 54.8% and the hospital mortality was 58.8%.
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references (p. 30-32).
DegreePostgraduate Diploma in Infectious Diseases
SubjectMycobacterium tuberculosis -- China -- Hong Kong.
Dept/ProgramMicrobiology
Persistent Identifierhttp://hdl.handle.net/10722/173736

 

DC FieldValueLanguage
dc.contributor.authorHo, Ka-yee, Jasperineen_HK
dc.contributor.author何家儀zh_HK
dc.date.accessioned2012-11-01T02:50:31Z-
dc.date.available2012-11-01T02:50:31Z-
dc.date.issued2012en_US
dc.identifier.urihttp://hdl.handle.net/10722/173736-
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.en_US
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."en_US
dc.descriptionIncludes bibliographical references (p. 30-32).en_US
dc.description.abstractBackground Mycobacterium tuberculosis (MTB) is an endemic disease in Hong Kong. The annual notification rate was 74.2 per 100, 000 population (1) compared with 3.8 per 100,000 population in the United States in 2009 (2). The reported hospital mortality of MTB admitted to intensive care unit (ICU) was 67-81% (3). This study aims at reviewing the characteristics and outcomes of pulmonary tuberculosis patients admitted to ICU in a local tertiary hospital. Objective To describe the demographic data, all-cause mortality, rate of developing concomitant bacterial infection, anti-tuberculosis drugs prescription pattern and the rate of drug induced side effects such as hepatotoxicity in patients with tuberculosis admitted to ICU. Design Retrospective descriptive study conducted in a mixed surgical and medical ICU in Hong Kong. Patients were critically ill patients diagnosed to have active MTB from January 2004 to December 2009. Results Eighty five patients were identified with active MTB in the study period. The mean age was 55.1±1.7 years old. Twenty six (30.6%) of the patients were above 65 years old. Seventy one (83.5%) of the patients were male. Twenty one (24.7%) of the patients had history of tuberculosis. Thirty two (37.7%) of the patients presented with fever for more than 1 week; 35 patients (41.2%) presented with subjective weight lost and 60% admitted to ICU due to respiratory failure. Sixty nine (81.2%) of the patients were intubated. Fifty seven (67.1%) of the patients had at least four types of anti-TB drugs started during hospitalization. Sixty (70%) of the patients had both isoniazid and rifampicin included in their anti-TB regimen. Eleven (16.7%) of the patients receiving anti-TB treatment were complicated with drug-induced hepatotoxicity. Thirteen (15.3%) patients were diagnosed by physicians to have hospital acquired pneumonia during ICU stay. The ICU all-cause mortality was 54.8% and the hospital mortality was 58.8%.en_US
dc.languageengen_US
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.en_US
dc.subject.lcshMycobacterium tuberculosis -- China -- Hong Kong.en_US
dc.titleA retrospective descriptive study on pulmonary tuberculosis patients in ICUen_HK
dc.typePG_Thesisen_US
dc.identifier.hkulb4832040en_US
dc.description.thesisnamePostgraduate Diploma in Infectious Diseasesen_US
dc.description.thesislevelPostgraduate diplomaen_US
dc.description.thesisdisciplineMicrobiologyen_US
dc.description.naturepublished_or_final_versionen_US

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