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Postgraduate Thesis: A retrospective descriptive study on pulmonary tuberculosis patients in ICU
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TitleA retrospective descriptive study on pulmonary tuberculosis patients in ICU
 
AuthorsHo, Ka-yee, Jasperine
何家儀
 
Issue Date2012
 
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
AbstractBackground Mycobacterium tuberculosis (MTB) is an endemic disease in Hong Kong. The annual notification rate was 74.2 per 100, 000 population (1) compared with 3.8 per 100,000 population in the United States in 2009 (2). The reported hospital mortality of MTB admitted to intensive care unit (ICU) was 67-81% (3). This study aims at reviewing the characteristics and outcomes of pulmonary tuberculosis patients admitted to ICU in a local tertiary hospital. Objective To describe the demographic data, all-cause mortality, rate of developing concomitant bacterial infection, anti-tuberculosis drugs prescription pattern and the rate of drug induced side effects such as hepatotoxicity in patients with tuberculosis admitted to ICU. Design Retrospective descriptive study conducted in a mixed surgical and medical ICU in Hong Kong. Patients were critically ill patients diagnosed to have active MTB from January 2004 to December 2009. Results Eighty five patients were identified with active MTB in the study period. The mean age was 55.1±1.7 years old. Twenty six (30.6%) of the patients were above 65 years old. Seventy one (83.5%) of the patients were male. Twenty one (24.7%) of the patients had history of tuberculosis. Thirty two (37.7%) of the patients presented with fever for more than 1 week; 35 patients (41.2%) presented with subjective weight lost and 60% admitted to ICU due to respiratory failure. Sixty nine (81.2%) of the patients were intubated. Fifty seven (67.1%) of the patients had at least four types of anti-TB drugs started during hospitalization. Sixty (70%) of the patients had both isoniazid and rifampicin included in their anti-TB regimen. Eleven (16.7%) of the patients receiving anti-TB treatment were complicated with drug-induced hepatotoxicity. Thirteen (15.3%) patients were diagnosed by physicians to have hospital acquired pneumonia during ICU stay. The ICU all-cause mortality was 54.8% and the hospital mortality was 58.8%.
 
DescriptionThesis (P. Dip.)--University of Hong Kong, 2012.
"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
Includes bibliographical references (p. 30-32).
 
DegreePostgraduate Diploma in Infectious Diseases
 
SubjectMycobacterium tuberculosis -- China -- Hong Kong.
 
Dept/ProgramMicrobiology
 
DC FieldValue
dc.contributor.authorHo, Ka-yee, Jasperine
 
dc.contributor.author何家儀
 
dc.date.accessioned2012-11-01T02:50:31Z
 
dc.date.available2012-11-01T02:50:31Z
 
dc.date.issued2012
 
dc.description.abstractBackground Mycobacterium tuberculosis (MTB) is an endemic disease in Hong Kong. The annual notification rate was 74.2 per 100, 000 population (1) compared with 3.8 per 100,000 population in the United States in 2009 (2). The reported hospital mortality of MTB admitted to intensive care unit (ICU) was 67-81% (3). This study aims at reviewing the characteristics and outcomes of pulmonary tuberculosis patients admitted to ICU in a local tertiary hospital. Objective To describe the demographic data, all-cause mortality, rate of developing concomitant bacterial infection, anti-tuberculosis drugs prescription pattern and the rate of drug induced side effects such as hepatotoxicity in patients with tuberculosis admitted to ICU. Design Retrospective descriptive study conducted in a mixed surgical and medical ICU in Hong Kong. Patients were critically ill patients diagnosed to have active MTB from January 2004 to December 2009. Results Eighty five patients were identified with active MTB in the study period. The mean age was 55.1±1.7 years old. Twenty six (30.6%) of the patients were above 65 years old. Seventy one (83.5%) of the patients were male. Twenty one (24.7%) of the patients had history of tuberculosis. Thirty two (37.7%) of the patients presented with fever for more than 1 week; 35 patients (41.2%) presented with subjective weight lost and 60% admitted to ICU due to respiratory failure. Sixty nine (81.2%) of the patients were intubated. Fifty seven (67.1%) of the patients had at least four types of anti-TB drugs started during hospitalization. Sixty (70%) of the patients had both isoniazid and rifampicin included in their anti-TB regimen. Eleven (16.7%) of the patients receiving anti-TB treatment were complicated with drug-induced hepatotoxicity. Thirteen (15.3%) patients were diagnosed by physicians to have hospital acquired pneumonia during ICU stay. The ICU all-cause mortality was 54.8% and the hospital mortality was 58.8%.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionThesis (P. Dip.)--University of Hong Kong, 2012.
 
dc.description"This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK)."
 
dc.descriptionIncludes bibliographical references (p. 30-32).
 
dc.description.thesisdisciplineMicrobiology
 
dc.description.thesislevelPostgraduate diploma
 
dc.description.thesisnamePostgraduate Diploma in Infectious Diseases
 
dc.identifier.hkulb4832040
 
dc.identifier.urihttp://hdl.handle.net/10722/173736
 
dc.languageeng
 
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.
 
dc.subject.lcshMycobacterium tuberculosis -- China -- Hong Kong.
 
dc.titleA retrospective descriptive study on pulmonary tuberculosis patients in ICU
 
dc.typePG_Thesis
 
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<item><contributor.author>Ho, Ka-yee, Jasperine</contributor.author>
<contributor.author>&#20309;&#23478;&#20736;</contributor.author>
<date.accessioned>2012-11-01T02:50:31Z</date.accessioned>
<date.available>2012-11-01T02:50:31Z</date.available>
<date.issued>2012</date.issued>
<identifier.uri>http://hdl.handle.net/10722/173736</identifier.uri>
<description>Thesis (P. Dip.)--University of Hong Kong, 2012.</description>
<description>&quot;This work is submitted to Faculty of Medicine of the University of Hong Kong in partial fulfillment of the requirements for the Postgraduate Diploma in Infectious Diseases, PDipID (HK).&quot;</description>
<description>Includes bibliographical references (p. 30-32).</description>
<description.abstract>Background
Mycobacterium tuberculosis (MTB) is an endemic disease in Hong Kong. The
annual notification rate was 74.2 per 100, 000 population (1) compared with 3.8 per
100,000 population in the United States in 2009 (2). The reported hospital mortality of
MTB admitted to intensive care unit (ICU) was 67-81% (3). This study aims at
reviewing the characteristics and outcomes of pulmonary tuberculosis patients
admitted to ICU in a local tertiary hospital.
Objective
To describe the demographic data, all-cause mortality, rate of developing
concomitant bacterial infection, anti-tuberculosis drugs prescription pattern and the
rate of drug induced side effects such as hepatotoxicity in patients with tuberculosis
admitted to ICU.
Design
Retrospective descriptive study conducted in a mixed surgical and medical ICU
in Hong Kong. Patients were critically ill patients diagnosed to have active MTB from
January 2004 to December 2009.
Results
Eighty five patients were identified with active MTB in the study period. The
mean age was 55.1&#177;1.7 years old. Twenty six (30.6%) of the patients were above 65
years old. Seventy one (83.5%) of the patients were male. Twenty one (24.7%) of the
patients had history of tuberculosis. Thirty two (37.7%) of the patients presented with
fever for more than 1 week; 35 patients (41.2%) presented with subjective weight lost
and 60% admitted to ICU due to respiratory failure. Sixty nine (81.2%) of the patients
were intubated. Fifty seven (67.1%) of the patients had at least four types of anti-TB
drugs started during hospitalization. Sixty (70%) of the patients had both isoniazid
and rifampicin included in their anti-TB regimen. Eleven (16.7%) of the patients
receiving anti-TB treatment were complicated with drug-induced hepatotoxicity.
Thirteen (15.3%) patients were diagnosed by physicians to have hospital acquired
pneumonia during ICU stay. The ICU all-cause mortality was 54.8% and the hospital
mortality was 58.8%.</description.abstract>
<language>eng</language>
<publisher>The University of Hong Kong (Pokfulam, Hong Kong)</publisher>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The author retains all proprietary rights, (such as patent rights) and the right to use in future works.</rights>
<subject.lcsh>Mycobacterium tuberculosis -- China -- Hong Kong.</subject.lcsh>
<title>A retrospective descriptive study on pulmonary tuberculosis patients in ICU</title>
<type>PG_Thesis</type>
<identifier.hkul>b4832040</identifier.hkul>
<description.thesisname>Postgraduate Diploma in Infectious Diseases</description.thesisname>
<description.thesislevel>Postgraduate diploma</description.thesislevel>
<description.thesisdiscipline>Microbiology</description.thesisdiscipline>
<description.nature>published_or_final_version</description.nature>
<bitstream.url>http://hub.hku.hk/bitstream/10722/173736/1/FullText.pdf</bitstream.url>
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