File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Third pathway: Endothelium-dependent hyperpolarization

TitleThird pathway: Endothelium-dependent hyperpolarization
Authors
KeywordsBlood Vessel
Endothelium
Potassium Channel
Smooth Muscle
Vasodilatation
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597
Citation
Drug Development Research, 2003, v. 58 n. 1, p. 18-22 How to Cite?
AbstractThe mechanism of endothelium-dependent hyperpolarizations, once attributed to an elusive endothelium-derived hyperpolarizing factor (EDHF), is better understood. The first steps involve an increase in the intracellular calcium concentration of the endothelial cells followed by the opening of endothelial calcium-activated potassium channels and the hyperpolarization of the endothelial cells. In certain arteries, these endothelial events are under the control of the endothelial cytochrome P450 monooxygenase. Then, the endothelium-dependent hyperpolarization of the smooth muscle cells can be evoked by direct electrical coupling through myo-endothelial junctions, accumulation of potassium ions in the intracellular space between the endothelial and the smooth muscle cells, and in rare occasions the release of a metabolite(s) of arachidonic acid via the cytochrome P450 pathway. These various mechanisms are not necessarily exclusive and can occur simultaneously and even in synergy. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/173542
ISSN
2015 Impact Factor: 0.984
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFélétou, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:36Z-
dc.date.available2012-10-30T06:32:36Z-
dc.date.issued2003en_US
dc.identifier.citationDrug Development Research, 2003, v. 58 n. 1, p. 18-22en_US
dc.identifier.issn0272-4391en_US
dc.identifier.urihttp://hdl.handle.net/10722/173542-
dc.description.abstractThe mechanism of endothelium-dependent hyperpolarizations, once attributed to an elusive endothelium-derived hyperpolarizing factor (EDHF), is better understood. The first steps involve an increase in the intracellular calcium concentration of the endothelial cells followed by the opening of endothelial calcium-activated potassium channels and the hyperpolarization of the endothelial cells. In certain arteries, these endothelial events are under the control of the endothelial cytochrome P450 monooxygenase. Then, the endothelium-dependent hyperpolarization of the smooth muscle cells can be evoked by direct electrical coupling through myo-endothelial junctions, accumulation of potassium ions in the intracellular space between the endothelial and the smooth muscle cells, and in rare occasions the release of a metabolite(s) of arachidonic acid via the cytochrome P450 pathway. These various mechanisms are not necessarily exclusive and can occur simultaneously and even in synergy. © 2003 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597en_US
dc.relation.ispartofDrug Development Researchen_US
dc.subjectBlood Vesselen_US
dc.subjectEndotheliumen_US
dc.subjectPotassium Channelen_US
dc.subjectSmooth Muscleen_US
dc.subjectVasodilatationen_US
dc.titleThird pathway: Endothelium-dependent hyperpolarizationen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ddr.10125en_US
dc.identifier.scopuseid_2-s2.0-0037282549en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037282549&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume58en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:000181384400003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridFélétou, M=7006461826en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats