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Conference Paper: Endothelium-derived hyperpolarizing factor: A key mediator of the vasodilator action of bradykinin

TitleEndothelium-derived hyperpolarizing factor: A key mediator of the vasodilator action of bradykinin
Authors
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immpharm
Citation
Immunopharmacology, 1996, v. 33 n. 1-3, p. 46-50 How to Cite?
AbstractBradykinin causes vasodilatation by stimulating the production of vasodilator prostanoids and nitric oxide (NO). However, there is an additional component that is mediated by a diffusible endothelium-derived hyperpolarizing factor (EDHF). The non-selective inhibitor of arachidonic acid metabolism eicosatetraenoic acid inhibits the EDHF-mediated component of the relaxation to bradykinin. Therefore, EDHF may be an arachidonic acid metabolite. The diffusible nature of EDHF has been disputed because of the inability to consistently detect the factor using perfusion bioassay techniques. However, administration of the acyltransferase inhibitor thimerosal facilitates the release of EDHF by endothelial cells in culture. Further studies are warranted to identify EDHF and explore further its functions in vasomotion.
Persistent Identifierhttp://hdl.handle.net/10722/173527
ISSN
2002 Impact Factor: 4.202
2003 SCImago Journal Rankings: 1.377
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorBissiriou, Ien_US
dc.contributor.authorAgboton, Ven_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:31Z-
dc.date.available2012-10-30T06:32:31Z-
dc.date.issued1996en_US
dc.identifier.citationImmunopharmacology, 1996, v. 33 n. 1-3, p. 46-50en_US
dc.identifier.issn0162-3109en_US
dc.identifier.urihttp://hdl.handle.net/10722/173527-
dc.description.abstractBradykinin causes vasodilatation by stimulating the production of vasodilator prostanoids and nitric oxide (NO). However, there is an additional component that is mediated by a diffusible endothelium-derived hyperpolarizing factor (EDHF). The non-selective inhibitor of arachidonic acid metabolism eicosatetraenoic acid inhibits the EDHF-mediated component of the relaxation to bradykinin. Therefore, EDHF may be an arachidonic acid metabolite. The diffusible nature of EDHF has been disputed because of the inability to consistently detect the factor using perfusion bioassay techniques. However, administration of the acyltransferase inhibitor thimerosal facilitates the release of EDHF by endothelial cells in culture. Further studies are warranted to identify EDHF and explore further its functions in vasomotion.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immpharmen_US
dc.relation.ispartofImmunopharmacologyen_US
dc.subject.mesh5,8,11,14-Eicosatetraynoic Acid - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic Acid - Metabolismen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshBiological Factors - Analysis - Physiologyen_US
dc.subject.meshBradykinin - Pharmacology - Physiologyen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshReceptor, Bradykinin B2en_US
dc.subject.meshReceptors, Bradykinin - Physiologyen_US
dc.subject.meshVasodilation - Drug Effects - Physiologyen_US
dc.titleEndothelium-derived hyperpolarizing factor: A key mediator of the vasodilator action of bradykininen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0162-3109(96)00083-5en_US
dc.identifier.pmid8856114-
dc.identifier.scopuseid_2-s2.0-0030175762en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030175762&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue1-3en_US
dc.identifier.spage46en_US
dc.identifier.epage50en_US
dc.identifier.isiWOS:A1996VA29800008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridBissiriou, I=8052855800en_US
dc.identifier.scopusauthoridAgboton, V=8052855900en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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