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Conference Paper: Endothelium-derived relaxing factors

TitleEndothelium-derived relaxing factors
Authors
KeywordsAtherosclerosis
Edhf
Edrf
Endothelium
Vascular Smooth Muscle
Vasospasm
Issue Date1995
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/ejmech
Citation
European Journal Of Medicinal Chemistry, 1995, v. 30 SUPPL., p. 361s-370s How to Cite?
AbstractThe endothelium plays an essential role in mediating relaxations of vascular smooth muscle in response to acetylcholine and other vasodilators. Indeed, endothelial cells can release several relaxing substances. The release is activated by a variety of agents including circulating hormones, autacoids, and products liberated by aggregating platelets, but also by changes in shear stress exerted by the blood. The major endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) formed enzymatically from L-arginine by the constitutive NO-synthase of the endothelial cells. Endothelium-dependent relaxations caused by EDRF are accompanied by increases in the activity of the soluble guanylate cyclase of the vascular smooth muscle cells. Other relaxing factors, such as prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) contribute to endothelium-dependent relaxations. In certain clinical situations an impairment of the production of EDRF (and EDHF?) may contribute to the occurrence of localized vasospasm or generalized increases in peripheral resistance, and set in motion the atherosclerotic process.
Persistent Identifierhttp://hdl.handle.net/10722/173525
ISSN
2015 Impact Factor: 3.902
2015 SCImago Journal Rankings: 1.184

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:30Z-
dc.date.available2012-10-30T06:32:30Z-
dc.date.issued1995en_US
dc.identifier.citationEuropean Journal Of Medicinal Chemistry, 1995, v. 30 SUPPL., p. 361s-370sen_US
dc.identifier.issn0223-5234en_US
dc.identifier.urihttp://hdl.handle.net/10722/173525-
dc.description.abstractThe endothelium plays an essential role in mediating relaxations of vascular smooth muscle in response to acetylcholine and other vasodilators. Indeed, endothelial cells can release several relaxing substances. The release is activated by a variety of agents including circulating hormones, autacoids, and products liberated by aggregating platelets, but also by changes in shear stress exerted by the blood. The major endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) formed enzymatically from L-arginine by the constitutive NO-synthase of the endothelial cells. Endothelium-dependent relaxations caused by EDRF are accompanied by increases in the activity of the soluble guanylate cyclase of the vascular smooth muscle cells. Other relaxing factors, such as prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) contribute to endothelium-dependent relaxations. In certain clinical situations an impairment of the production of EDRF (and EDHF?) may contribute to the occurrence of localized vasospasm or generalized increases in peripheral resistance, and set in motion the atherosclerotic process.en_US
dc.languageengen_US
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/ejmechen_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.subjectAtherosclerosisen_US
dc.subjectEdhfen_US
dc.subjectEdrfen_US
dc.subjectEndotheliumen_US
dc.subjectVascular Smooth Muscleen_US
dc.subjectVasospasmen_US
dc.titleEndothelium-derived relaxing factorsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0029010176en_US
dc.identifier.volume30en_US
dc.identifier.issueSUPPL.en_US
dc.identifier.spage361sen_US
dc.identifier.epage370sen_US
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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