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Conference Paper: Inducible nitric oxide synthase in vascular smooth muscle

TitleInducible nitric oxide synthase in vascular smooth muscle
Authors
Issue Date1994
Citation
Arzneimittel-Forschung/Drug Research, 1994, v. 44 n. 3 A, p. 432-435 How to Cite?
AbstractNitric oxide is a multifunctional regulator of the vascular system. In healthy blood vessels, nitric oxide is produced from L-arginine by the constitutive nitric oxide synthase in endothelial cells. In addition, vascular injury or inflammation cause the production of nitric oxide in most types of vascular cells, including vascular smooth muscle. This response to injury is due to the induction of a second type of nitric oxide synthase by cytokines such as interleukin-1β or tumor necrosis factor-α. Factors derived from blood (thrombin, plasmin) and from vascular cells (platelet-derived growth factor, transforming growth factor β, insulin-like growth factor, epidermal growth factor and basic fibroblast growth factor), regulate the induction of nitric oxide synthesis in vascular smooth muscle cells. The endogenous production of nitric oxide by vascular smooth muscle at sites of injury may contribute to the local control of blood flow, vascular tone and blood fluidity. It may participate also to the remodeling of the injured blood vessel wall.
Persistent Identifierhttp://hdl.handle.net/10722/173522
ISSN
2014 Impact Factor: 0.701
2015 SCImago Journal Rankings: 0.212

 

DC FieldValueLanguage
dc.contributor.authorSchini, VBen_US
dc.contributor.authorBusse, Ren_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:29Z-
dc.date.available2012-10-30T06:32:29Z-
dc.date.issued1994en_US
dc.identifier.citationArzneimittel-Forschung/Drug Research, 1994, v. 44 n. 3 A, p. 432-435en_US
dc.identifier.issn0004-4172en_US
dc.identifier.urihttp://hdl.handle.net/10722/173522-
dc.description.abstractNitric oxide is a multifunctional regulator of the vascular system. In healthy blood vessels, nitric oxide is produced from L-arginine by the constitutive nitric oxide synthase in endothelial cells. In addition, vascular injury or inflammation cause the production of nitric oxide in most types of vascular cells, including vascular smooth muscle. This response to injury is due to the induction of a second type of nitric oxide synthase by cytokines such as interleukin-1β or tumor necrosis factor-α. Factors derived from blood (thrombin, plasmin) and from vascular cells (platelet-derived growth factor, transforming growth factor β, insulin-like growth factor, epidermal growth factor and basic fibroblast growth factor), regulate the induction of nitric oxide synthesis in vascular smooth muscle cells. The endogenous production of nitric oxide by vascular smooth muscle at sites of injury may contribute to the local control of blood flow, vascular tone and blood fluidity. It may participate also to the remodeling of the injured blood vessel wall.en_US
dc.languageengen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.subject.meshAmino Acid Oxidoreductases - Biosynthesis - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnzyme Induction - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth, Vascular - Enzymologyen_US
dc.subject.meshNitric Oxide - Biosynthesis - Physiologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshWounds And Injuries - Physiopathologyen_US
dc.titleInducible nitric oxide synthase in vascular smooth muscleen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7514415-
dc.identifier.scopuseid_2-s2.0-0028288342en_US
dc.identifier.volume44en_US
dc.identifier.issue3 Aen_US
dc.identifier.spage432en_US
dc.identifier.epage435en_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridBusse, R=7102661981en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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