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Conference Paper: Age-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery

TitleAge-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric artery
Authors
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S352-S354 How to Cite?
AbstractThe present study was designed to investigate the effects of age on the endothelium-dependent hyperpolarizing effect of endothelin-3 (ET-3) in the mesenteric artery of the rat. Main superior mesenteric arteries, with endothelium of young (7-9 weeks), adult (20-24 weeks), and old (40-50 weeks) male Wistar-Kyoto rats were studied. The cell membrane potential of the vascular smooth-muscle cells was measured with glass microelectrodes in the presence of indomethacin (inhibitor of cyclooxygenase) and N(G)-nitro-L- arginine (NLA, inhibitor of nitric oxide synthase). In preparations with endothelium from young rats, ET-3 produced transient hyperpolarizations in a concentration-dependent (10-8 to 10-9 M) manner. In tissues from adult rats, only a small hyperpolarization to the peptide was observed at 10-7 M, whereas no detectable membrane potential changes were observed in tissues from old animals. In tissues of all groups, acetylcholine produced concentration-dependent hyperpolarizations; the maximal amplitude of hyperpolarization was reduced in the old rats but no significant differences were observed in the threshold concentration for hyperpolarization to acetylcholine. These data suggest that aging decreases endothelium-dependent hyperpolarizations evoked by both ET-3 and acetylcholine.
Persistent Identifierhttp://hdl.handle.net/10722/173520
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNakashima, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:29Z-
dc.date.available2012-10-30T06:32:29Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S352-S354en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173520-
dc.description.abstractThe present study was designed to investigate the effects of age on the endothelium-dependent hyperpolarizing effect of endothelin-3 (ET-3) in the mesenteric artery of the rat. Main superior mesenteric arteries, with endothelium of young (7-9 weeks), adult (20-24 weeks), and old (40-50 weeks) male Wistar-Kyoto rats were studied. The cell membrane potential of the vascular smooth-muscle cells was measured with glass microelectrodes in the presence of indomethacin (inhibitor of cyclooxygenase) and N(G)-nitro-L- arginine (NLA, inhibitor of nitric oxide synthase). In preparations with endothelium from young rats, ET-3 produced transient hyperpolarizations in a concentration-dependent (10-8 to 10-9 M) manner. In tissues from adult rats, only a small hyperpolarization to the peptide was observed at 10-7 M, whereas no detectable membrane potential changes were observed in tissues from old animals. In tissues of all groups, acetylcholine produced concentration-dependent hyperpolarizations; the maximal amplitude of hyperpolarization was reduced in the old rats but no significant differences were observed in the threshold concentration for hyperpolarization to acetylcholine. These data suggest that aging decreases endothelium-dependent hyperpolarizations evoked by both ET-3 and acetylcholine.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshEndothelins - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMesenteric Arteries - Drug Effects - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.titleAge-dependent decrease in endothelium-dependent hyperpolarizations to endothelin-3 in the rat mesenteric arteryen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199322008-00092-
dc.identifier.pmid7509985-
dc.identifier.scopuseid_2-s2.0-0027773025en_US
dc.identifier.volume22en_US
dc.identifier.issueSUPPL. 8en_US
dc.identifier.spageS352en_US
dc.identifier.epageS354en_US
dc.identifier.isiWOS:A1993MN02800092-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNakashima, M=35599797500en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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