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Conference Paper: Endothelins 1 and 3 and big endothelin-1 contract isolated human placental veins

TitleEndothelins 1 and 3 and big endothelin-1 contract isolated human placental veins
Authors
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S278-S281 How to Cite?
AbstractExperiments were designed to investigate the reactivity of vascular smooth muscle to endothelins (ETs) in veins taken from human placentas immediately after delivery. The placental veins were cut into rings and suspended between two stirrups in conventional organ chambers (filled with aerated, modified Krebs-Ringer bicarbonate solution) for isometric recording of tension. ET-1 and ET-3 caused concentration-dependent contractions of the isolated human placental veins. The responses induced by ET-1 were greater than those evoked by ET-3 and were not significantly affected by BQ-123, a selective inhibitor of ET(A) receptors. Contractions to big ET-1 were obtained in rings both with and without endothelium; they were inhibited by phosphoramidon, an inhibitor of endothelin-converting enzyme. These findings indicate that the conversion of the precursor of ET-1 can occur in human placental veins. The receptors mediating the contraction of human placental veins to endothelins do not belong to the ET(A) subtype; the response to the peptides is probably mediated in part by an uncharacterized ET-receptor subtype and in part by ET(B) receptors. The output of big ET-1 in the vascular wall or from surrounding tissues in the placenta could be involved in the regulation of venous tone in this organ.
Persistent Identifierhttp://hdl.handle.net/10722/173516
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorLe, SQen_US
dc.contributor.authorWasserstrum, Nen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:28Z-
dc.date.available2012-10-30T06:32:28Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S278-S281en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173516-
dc.description.abstractExperiments were designed to investigate the reactivity of vascular smooth muscle to endothelins (ETs) in veins taken from human placentas immediately after delivery. The placental veins were cut into rings and suspended between two stirrups in conventional organ chambers (filled with aerated, modified Krebs-Ringer bicarbonate solution) for isometric recording of tension. ET-1 and ET-3 caused concentration-dependent contractions of the isolated human placental veins. The responses induced by ET-1 were greater than those evoked by ET-3 and were not significantly affected by BQ-123, a selective inhibitor of ET(A) receptors. Contractions to big ET-1 were obtained in rings both with and without endothelium; they were inhibited by phosphoramidon, an inhibitor of endothelin-converting enzyme. These findings indicate that the conversion of the precursor of ET-1 can occur in human placental veins. The receptors mediating the contraction of human placental veins to endothelins do not belong to the ET(A) subtype; the response to the peptides is probably mediated in part by an uncharacterized ET-receptor subtype and in part by ET(B) receptors. The output of big ET-1 in the vascular wall or from surrounding tissues in the placenta could be involved in the regulation of venous tone in this organ.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshEndothelin-1en_US
dc.subject.meshEndothelins - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlycopeptides - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIsometric Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPeptides, Cyclic - Pharmacologyen_US
dc.subject.meshPlacenta - Blood Supply - Drug Effectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProstaglandins - Pharmacologyen_US
dc.subject.meshProtein Precursors - Pharmacologyen_US
dc.subject.meshReceptors, Endothelin - Antagonists & Inhibitorsen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.titleEndothelins 1 and 3 and big endothelin-1 contract isolated human placental veinsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199322008-00073-
dc.identifier.pmid7509965-
dc.identifier.scopuseid_2-s2.0-0027732690en_US
dc.identifier.volume22en_US
dc.identifier.issueSUPPL. 8en_US
dc.identifier.spageS278en_US
dc.identifier.epageS281en_US
dc.identifier.isiWOS:A1993MN02800073-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridLe, SQ=7006184502en_US
dc.identifier.scopusauthoridWasserstrum, N=7004673923en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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