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Conference Paper: Role of the L-arginine-nitric oxide pathway in vascular smooth muscle

TitleRole of the L-arginine-nitric oxide pathway in vascular smooth muscle
Authors
Issue Date1993
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Heart Journal, 1993, v. 14 SUPPL. I, p. 16-21 How to Cite?
AbstractThis brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 β and tumour necrosis factor α, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide. The cytokines cause the synthesis of nitric oxide synthase(s), which catalyzes the conversion of L-arginine to nitric oxide and L-citrulline. The production of nitric oxide can be modulated by factors produced by vascular cells and formed elements of the blood (e.g. platelet-derived growth factor, transforming growth factor β), but also those generated at sites of vascular injury from inactive precursors circulating in the blood (e.g. thrombin, plasmin). The production of nitric oxide by vascular smooth muscle cells may contribute to the homeostasis of blood vessels at sites of injury. In particular, nitric oxide may prevent the local development of vasospasms, unwanted proliferation of smooth muscle cells, and also help to control coagulation and the formation of the thrombus.
Persistent Identifierhttp://hdl.handle.net/10722/173513
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSchini, VBen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:27Z-
dc.date.available2012-10-30T06:32:27Z-
dc.date.issued1993en_US
dc.identifier.citationEuropean Heart Journal, 1993, v. 14 SUPPL. I, p. 16-21en_US
dc.identifier.issn0195-668Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173513-
dc.description.abstractThis brief overview discusses the ability of mediators associated with vascular injury, such as interleukin-1 β and tumour necrosis factor α, to activate vascular smooth muscle cells to produce nitric oxide or a related donor of nitric oxide. The cytokines cause the synthesis of nitric oxide synthase(s), which catalyzes the conversion of L-arginine to nitric oxide and L-citrulline. The production of nitric oxide can be modulated by factors produced by vascular cells and formed elements of the blood (e.g. platelet-derived growth factor, transforming growth factor β), but also those generated at sites of vascular injury from inactive precursors circulating in the blood (e.g. thrombin, plasmin). The production of nitric oxide by vascular smooth muscle cells may contribute to the homeostasis of blood vessels at sites of injury. In particular, nitric oxide may prevent the local development of vasospasms, unwanted proliferation of smooth muscle cells, and also help to control coagulation and the formation of the thrombus.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/en_US
dc.relation.ispartofEuropean Heart Journalen_US
dc.subject.meshAmino Acid Oxidoreductases - Metabolismen_US
dc.subject.meshArginine - Metabolismen_US
dc.subject.meshBlood Vessels - Injuries - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth, Vascular - Metabolism - Physiopathologyen_US
dc.subject.meshNitric Oxide - Biosynthesisen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshPlatelet Activation - Physiologyen_US
dc.titleRole of the L-arginine-nitric oxide pathway in vascular smooth muscleen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7507437-
dc.identifier.scopuseid_2-s2.0-0027442854en_US
dc.identifier.volume14en_US
dc.identifier.issueSUPPL. Ien_US
dc.identifier.spage16en_US
dc.identifier.epage21en_US
dc.identifier.isiWOS:A1993MK92600004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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