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Conference Paper: Balloon injury induces nitric oxide synthase activity in rat carotid arteries

TitleBalloon injury induces nitric oxide synthase activity in rat carotid arteries
Authors
Issue Date1992
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1992, v. 20 SUPPL. 12, p. S151-S154 How to Cite?
AbstractExperiments were performed to investigate whether or not balloon injury induces nitric oxide (NO) synthase activity in the arterial wall removed. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and collected 24 h after the procedure, and in control right carotid arteries in which the endothelium was removed acutely. Phenylephrine evoked concentration-dependent contractions in balloon-injured and control carotid arteries without endothelium. However, in the balloon-injured carotid arteries, the concentration-contraction curves to phenylephrine were shifted significantly to the right compared to those observed in control carotid arteries without endothelium. In balloon-injured arteries, nitro-L-arginine restored full contractions, whereas superoxide dismutase potentiated the hyporesponsiveness to phenylephrine. The depressed contractions were associated with a concomitant increase in the basal level of guanosine-3',5'-cyclic monophosphate; this production was abolished by nitro-L-arginine. These observations indicate that in vivo endothelial injury of the rat carotid arteries induces the production of nitric oxide from L-arginine in the arterial wall.
Persistent Identifierhttp://hdl.handle.net/10722/173509
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJoly, GAen_US
dc.contributor.authorSchini, VBen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:25Z-
dc.date.available2012-10-30T06:32:25Z-
dc.date.issued1992en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1992, v. 20 SUPPL. 12, p. S151-S154en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173509-
dc.description.abstractExperiments were performed to investigate whether or not balloon injury induces nitric oxide (NO) synthase activity in the arterial wall removed. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and collected 24 h after the procedure, and in control right carotid arteries in which the endothelium was removed acutely. Phenylephrine evoked concentration-dependent contractions in balloon-injured and control carotid arteries without endothelium. However, in the balloon-injured carotid arteries, the concentration-contraction curves to phenylephrine were shifted significantly to the right compared to those observed in control carotid arteries without endothelium. In balloon-injured arteries, nitro-L-arginine restored full contractions, whereas superoxide dismutase potentiated the hyporesponsiveness to phenylephrine. The depressed contractions were associated with a concomitant increase in the basal level of guanosine-3',5'-cyclic monophosphate; this production was abolished by nitro-L-arginine. These observations indicate that in vivo endothelial injury of the rat carotid arteries induces the production of nitric oxide from L-arginine in the arterial wall.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAmino Acid Oxidoreductases - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshBalloon Dilation - Adverse Effectsen_US
dc.subject.meshCarotid Arteries - Enzymologyen_US
dc.subject.meshCyclic Gmp - Metabolismen_US
dc.subject.meshEndothelium, Vascular - Injuries - Physiologyen_US
dc.subject.meshEnzyme Inductionen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effects - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Enzymology - Physiologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSuperoxide Dismutase - Metabolismen_US
dc.titleBalloon injury induces nitric oxide synthase activity in rat carotid arteriesen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1282955-
dc.identifier.scopuseid_2-s2.0-0027097528en_US
dc.identifier.volume20en_US
dc.identifier.issueSUPPL. 12en_US
dc.identifier.spageS151en_US
dc.identifier.epageS154en_US
dc.identifier.isiWOS:A1992KF28300043-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJoly, GA=7005110329en_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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