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Conference Paper: Adrenergic and cholinergic regulation of bronchial vascular tone

TitleAdrenergic and cholinergic regulation of bronchial vascular tone
Authors
Issue Date1992
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Review Of Respiratory Disease, 1992, v. 146 n. 5 II, p. S11-S14 How to Cite?
AbstractThe autonomic nervous system plays a vital role in the regulation of vasomotor tone. Previous studies of systemic arteries and veins have shown that the classic autonomic neurotransmitters, norepinephrine and acetylcholine, act on smooth muscle, adrenergic nerve endings, and endothelial cells in the blood vessel wall to regulate vasomotor tone. Similar studies with isolated tissues indicate that bronchial arteries are innervated by adrenergic neurons and that norepinephrine activates postjunctional alpha1-adrenoceptors to cause smooth muscle contraction. Isolated canine bronchial arteries fall to relax in response to beta- adrenoceptor agonists, and they do not contract when exposed to acetylcholine. This lack of responsiveness may be species-specific, however, since isolated bronchial arteries from other species respond to these agonists. Acetylcholine causes endothelium-dependent relaxation of bronchial arteries in vitro; this response is mediated by endothelial M3-muscarinic receptors. The role of the endothelium in mediating responses to adrenergic agonists, as well as the prejunctional effects of norepinephrine and acetylcholine on adrenergic nerve endings, remain to be explored in isolated bronchial arteries.
Persistent Identifierhttp://hdl.handle.net/10722/173503
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorO'rourke, STen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:23Z-
dc.date.available2012-10-30T06:32:23Z-
dc.date.issued1992en_US
dc.identifier.citationAmerican Review Of Respiratory Disease, 1992, v. 146 n. 5 II, p. S11-S14en_US
dc.identifier.issn0003-0805en_US
dc.identifier.urihttp://hdl.handle.net/10722/173503-
dc.description.abstractThe autonomic nervous system plays a vital role in the regulation of vasomotor tone. Previous studies of systemic arteries and veins have shown that the classic autonomic neurotransmitters, norepinephrine and acetylcholine, act on smooth muscle, adrenergic nerve endings, and endothelial cells in the blood vessel wall to regulate vasomotor tone. Similar studies with isolated tissues indicate that bronchial arteries are innervated by adrenergic neurons and that norepinephrine activates postjunctional alpha1-adrenoceptors to cause smooth muscle contraction. Isolated canine bronchial arteries fall to relax in response to beta- adrenoceptor agonists, and they do not contract when exposed to acetylcholine. This lack of responsiveness may be species-specific, however, since isolated bronchial arteries from other species respond to these agonists. Acetylcholine causes endothelium-dependent relaxation of bronchial arteries in vitro; this response is mediated by endothelial M3-muscarinic receptors. The role of the endothelium in mediating responses to adrenergic agonists, as well as the prejunctional effects of norepinephrine and acetylcholine on adrenergic nerve endings, remain to be explored in isolated bronchial arteries.en_US
dc.languageengen_US
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_US
dc.relation.ispartofAmerican Review of Respiratory Diseaseen_US
dc.subject.meshAdrenergic Fibers - Drug Effects - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchial Arteries - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshCholinergic Fibers - Drug Effects - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshSwineen_US
dc.titleAdrenergic and cholinergic regulation of bronchial vascular toneen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1164/ajrccm/146.5_Pt_2.S11-
dc.identifier.pmid1443898-
dc.identifier.scopuseid_2-s2.0-0026483407en_US
dc.identifier.volume146en_US
dc.identifier.issue5 IIen_US
dc.identifier.spageS11en_US
dc.identifier.epageS14en_US
dc.identifier.isiWOS:A1992KA60400005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridO'Rourke, ST=7005313078en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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