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Conference Paper: Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders

TitleCalcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders
Authors
Issue Date1991
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1991, v. 18 SUPPL. 8, p. S1-S5 How to Cite?
AbstractRecent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention.
Persistent Identifierhttp://hdl.handle.net/10722/173501
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPeters, Ten_US
dc.contributor.authorWilffert, Ben_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorVan Zwieten, PAen_US
dc.date.accessioned2012-10-30T06:32:23Z-
dc.date.available2012-10-30T06:32:23Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1991, v. 18 SUPPL. 8, p. S1-S5en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173501-
dc.description.abstractRecent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshCalcium Channel Blockers - Therapeutic Useen_US
dc.subject.meshCalcium Channels - Physiologyen_US
dc.subject.meshNervous System Diseases - Drug Therapyen_US
dc.subject.meshNeurons - Drug Effects - Physiologyen_US
dc.titleCalcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disordersen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199118081-00002-
dc.identifier.pmid1726728-
dc.identifier.scopuseid_2-s2.0-0026377896en_US
dc.identifier.volume18en_US
dc.identifier.issueSUPPL. 8en_US
dc.identifier.spageS1en_US
dc.identifier.epageS5en_US
dc.identifier.isiWOS:A1991JF56700002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPeters, T=7402962977en_US
dc.identifier.scopusauthoridWilffert, B=7004787475en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridVan Zwieten, PA=36041684500en_US

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