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Conference Paper: Induction of endothelin secretion by angiotensin II: Effects on growth and synthetic activity of vascular smooth muscle cells

TitleInduction of endothelin secretion by angiotensin II: Effects on growth and synthetic activity of vascular smooth muscle cells
Authors
Issue Date1991
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1991, v. 17 SUPPL. 7, p. S96-S100 How to Cite?
AbstractAngiotensin II induces the synthesis and secretion of endothelin by cultured rat vascular smooth muscle cells. Previous studies demonstrate that angiotensin II also activates the synthesis of extracellular matrix-associated glycoconjugates (glycopeptides and proteoglycans) by cultured smooth muscle cells. Furthermore, in culture medium containing mitogen-depleted, plasma-derived serum (1.0%), angiotensin II stimulates the growth of rat smooth muscle cells. Therefore, the influence of endothelin-1 (ET-1) on the growth and matrix elaboration by cultured rat smooth muscle cells was studied to assess its contribution to the stimulatory activity of angiotensin II. In quiescent cultures of smooth muscle cells, no stimulation of the incorporation of [3H]thymidine into DNA by ET-1 was apparent, even at maximal doses (10-7 M). Under the same conditions, the synthesis of extracellular matrix glycoconjugate material was not enhanced by ET-1, unlike angiotensin II. In cultures maintained in medium containing 1.0% plasma-derived serum, ET-1 was incapable of stimulating either proliferation or incorporation of [3H]thymidine into DNA whereas angiotensin II stimulated both activities. ET-1, however, did induce the expression of growth factor and thrombospondin genes in quiescent smooth muscle cultures. The data suggest that growth stimulation of smooth muscle cells by angiotensin II does not occur as a consequence of stimulated ET-1 production.
Persistent Identifierhttp://hdl.handle.net/10722/173496
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorScottBurden, Ten_US
dc.contributor.authorResink, TJen_US
dc.contributor.authorHahn, AWAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:21Z-
dc.date.available2012-10-30T06:32:21Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1991, v. 17 SUPPL. 7, p. S96-S100en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173496-
dc.description.abstractAngiotensin II induces the synthesis and secretion of endothelin by cultured rat vascular smooth muscle cells. Previous studies demonstrate that angiotensin II also activates the synthesis of extracellular matrix-associated glycoconjugates (glycopeptides and proteoglycans) by cultured smooth muscle cells. Furthermore, in culture medium containing mitogen-depleted, plasma-derived serum (1.0%), angiotensin II stimulates the growth of rat smooth muscle cells. Therefore, the influence of endothelin-1 (ET-1) on the growth and matrix elaboration by cultured rat smooth muscle cells was studied to assess its contribution to the stimulatory activity of angiotensin II. In quiescent cultures of smooth muscle cells, no stimulation of the incorporation of [3H]thymidine into DNA by ET-1 was apparent, even at maximal doses (10-7 M). Under the same conditions, the synthesis of extracellular matrix glycoconjugate material was not enhanced by ET-1, unlike angiotensin II. In cultures maintained in medium containing 1.0% plasma-derived serum, ET-1 was incapable of stimulating either proliferation or incorporation of [3H]thymidine into DNA whereas angiotensin II stimulated both activities. ET-1, however, did induce the expression of growth factor and thrombospondin genes in quiescent smooth muscle cultures. The data suggest that growth stimulation of smooth muscle cells by angiotensin II does not occur as a consequence of stimulated ET-1 production.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAngiotensin Ii - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDna - Analysis - Biosynthesisen_US
dc.subject.meshEndothelins - Secretionen_US
dc.subject.meshGlycine - Metabolismen_US
dc.subject.meshMuscle, Smooth, Vascular - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshRna - Analysis - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshThymidine - Metabolismen_US
dc.titleInduction of endothelin secretion by angiotensin II: Effects on growth and synthetic activity of vascular smooth muscle cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199100177-00025-
dc.identifier.pmid1725442-
dc.identifier.scopuseid_2-s2.0-0026317420en_US
dc.identifier.volume17en_US
dc.identifier.issueSUPPL. 7en_US
dc.identifier.spageS96en_US
dc.identifier.epageS100en_US
dc.identifier.isiWOS:A1991GU39600025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridScottBurden, T=7004306459en_US
dc.identifier.scopusauthoridResink, TJ=7005480570en_US
dc.identifier.scopusauthoridHahn, AWA=7202403183en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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