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Conference Paper: Endothelium-dependent contractions

TitleEndothelium-dependent contractions
Authors
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1991, v. 28 n. 1-3, p. 74-83 How to Cite?
AbstractThe endothelial cells help to control the tone of the underlying vascular smooth muscle by releasing vasoactive factors. In physiological circumstances, the release of relaxing factors (nitric oxide and endothelium-derived hyperpolarizing factor) appears to predominate. However, in certain blood vessels (peripheral veins and large cerebral arteries), the normal endothelium has the propensity to release vasoconstrictor substances, among which are superoxide anion and thromboxane A 2; the release of these endothelium-derived vasoconstrictors may contribute to the autoregulatory processes. In most blood vessels, anoxic conditions initiate the release of an unidentified endothelium-dependent contracting fractor. Cultured endothelial cells, and blood vessels maintained under culture conditions for prolonged periods of time, release the vasoconstrictor peptide endothelin. A characteristic of vascular diseases is that the ability of the endothelial cells to release relaxing factor(s) is reduced, while the generation of contracting factor is maintained or enhanced.
Persistent Identifierhttp://hdl.handle.net/10722/173495
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorGraser, Ten_US
dc.date.accessioned2012-10-30T06:32:21Z-
dc.date.available2012-10-30T06:32:21Z-
dc.date.issued1991en_US
dc.identifier.citationBlood Vessels, 1991, v. 28 n. 1-3, p. 74-83en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/173495-
dc.description.abstractThe endothelial cells help to control the tone of the underlying vascular smooth muscle by releasing vasoactive factors. In physiological circumstances, the release of relaxing factors (nitric oxide and endothelium-derived hyperpolarizing factor) appears to predominate. However, in certain blood vessels (peripheral veins and large cerebral arteries), the normal endothelium has the propensity to release vasoconstrictor substances, among which are superoxide anion and thromboxane A 2; the release of these endothelium-derived vasoconstrictors may contribute to the autoregulatory processes. In most blood vessels, anoxic conditions initiate the release of an unidentified endothelium-dependent contracting fractor. Cultured endothelial cells, and blood vessels maintained under culture conditions for prolonged periods of time, release the vasoconstrictor peptide endothelin. A characteristic of vascular diseases is that the ability of the endothelial cells to release relaxing factor(s) is reduced, while the generation of contracting factor is maintained or enhanced.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshEndothelins - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshMuscle Contraction - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Metabolismen_US
dc.titleEndothelium-dependent contractionsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1900447-
dc.identifier.scopuseid_2-s2.0-0026078824en_US
dc.identifier.volume28en_US
dc.identifier.issue1-3en_US
dc.identifier.spage74en_US
dc.identifier.epage83en_US
dc.identifier.isiWOS:A1991FB33600011-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridGraser, T=7005581334en_US

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