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Conference Paper: Hypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating platelets

TitleHypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating platelets
Authors
Issue Date1991
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
European Heart Journal, 1991, v. 12 SUPPL. E, p. 25-32 How to Cite?
AbstractIn pig coronary arteries atherosclerosis developed progressively after an experimental mechanical injury to the endothelium, despite its regeneration. The atherosclerotic process can be considerably accelerated by a high cholesterol diet. In arteries with regenerated endothelium, there is a reduction of endothelium-dependent relaxations mediated by (a) pertussis toxin-sensitive G protein(s). As this includes the response to platelet-derived serotonin, the ability of the regenerated endothelium to prevent abnormal vasoconstrictions (and presumably to feedback on platelet aggregation) in response to aggregating platelets is seriously curtailed. These changes are exacerbated in atherosclerotic arteries. Bioassay studies demonstrate that reduced endothelium-dependent relaxations are due mainly to a reduced release of endothelium-derived relaxing factor. Thus, endothelial dysfunction, in particular the reduced ability to release endothelium-derived relaxing factor, is a key factor in determining the abnormal responsiveness of the atherosclerotic blood vessel wall.
Persistent Identifierhttp://hdl.handle.net/10722/173494
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:21Z-
dc.date.available2012-10-30T06:32:21Z-
dc.date.issued1991en_US
dc.identifier.citationEuropean Heart Journal, 1991, v. 12 SUPPL. E, p. 25-32en_US
dc.identifier.issn0195-668Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173494-
dc.description.abstractIn pig coronary arteries atherosclerosis developed progressively after an experimental mechanical injury to the endothelium, despite its regeneration. The atherosclerotic process can be considerably accelerated by a high cholesterol diet. In arteries with regenerated endothelium, there is a reduction of endothelium-dependent relaxations mediated by (a) pertussis toxin-sensitive G protein(s). As this includes the response to platelet-derived serotonin, the ability of the regenerated endothelium to prevent abnormal vasoconstrictions (and presumably to feedback on platelet aggregation) in response to aggregating platelets is seriously curtailed. These changes are exacerbated in atherosclerotic arteries. Bioassay studies demonstrate that reduced endothelium-dependent relaxations are due mainly to a reduced release of endothelium-derived relaxing factor. Thus, endothelial dysfunction, in particular the reduced ability to release endothelium-derived relaxing factor, is a key factor in determining the abnormal responsiveness of the atherosclerotic blood vessel wall.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/en_US
dc.relation.ispartofEuropean Heart Journalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteriosclerosis - Physiopathologyen_US
dc.subject.meshBlood Platelets - Metabolismen_US
dc.subject.meshEndothelium, Vascular - Metabolismen_US
dc.subject.meshHypercholesterolemia - Physiopathologyen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshPlatelet Aggregation - Physiologyen_US
dc.titleHypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating plateletsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/eurheartj/12.suppl_E.25-
dc.identifier.pmid1790781-
dc.identifier.scopuseid_2-s2.0-0026062979en_US
dc.identifier.volume12en_US
dc.identifier.issueSUPPL. Een_US
dc.identifier.spage25en_US
dc.identifier.epage32en_US
dc.identifier.isiWOS:A1991GP79700005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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