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Conference Paper: L-arginine evokes relaxations of the rat aorta in both the presence and absence of endothelial cells

TitleL-arginine evokes relaxations of the rat aorta in both the presence and absence of endothelial cells
Authors
KeywordsBasic Cationic Amino Acids
Endothelium
L-Arginine
Methylene Blue
Nitro-L-Arginine
Issue Date1991
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1991, v. 17 SUPPL. 3, p. S10-S14 How to Cite?
AbstractThe effect of L-arginine [the substrate for the formation of nitric oxide (NO) in endothelial cells] on the reactivity of isolated vascular preparations was studied. Rings of rat aorta, with or without endothelium, were suspended in organ chambers for the measurement of isometric force. After various incubation periods in physiological salt solution (37°C, 95% O2 and 5% CO2), they were contracted with phenylephrine (10-6 M) before the addition of cumulative concentrations of L-arginine. L-Arginine evoked only minor changes in tension in preparations incubated for 0.5 h. However, when the incubation period was longer than 2 h, the amino acid evoked concentration- and time-dependent relaxations in preparations both with and without endothelium. The relaxations evoked by L-arginine were impaired by nitro-L-arginine and methylene blue. Other basic cationic amino acids (D-arginine, L-homoarginine, L-citrulline, L-lysine, and L-ornithine) evoked only small or no relaxations in both types of preparations. These observations demonstrate that L-arginine stereoselectively and specifically relaxes the rat aorta whether or not it contains the endothelium; this response depends on the duration of the prior incubation of the rings in physiological salt solution. The relaxations are impaired by inhibitors of both the formation and the action of NO, demonstrating that the endothelial cells and the vascular smooth muscle of the rat aorta possess an L-arginine - NO pathway(s) associated with relaxation.
Persistent Identifierhttp://hdl.handle.net/10722/173488
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962

 

DC FieldValueLanguage
dc.contributor.authorSchini, VBen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:19Z-
dc.date.available2012-10-30T06:32:19Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1991, v. 17 SUPPL. 3, p. S10-S14en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/173488-
dc.description.abstractThe effect of L-arginine [the substrate for the formation of nitric oxide (NO) in endothelial cells] on the reactivity of isolated vascular preparations was studied. Rings of rat aorta, with or without endothelium, were suspended in organ chambers for the measurement of isometric force. After various incubation periods in physiological salt solution (37°C, 95% O2 and 5% CO2), they were contracted with phenylephrine (10-6 M) before the addition of cumulative concentrations of L-arginine. L-Arginine evoked only minor changes in tension in preparations incubated for 0.5 h. However, when the incubation period was longer than 2 h, the amino acid evoked concentration- and time-dependent relaxations in preparations both with and without endothelium. The relaxations evoked by L-arginine were impaired by nitro-L-arginine and methylene blue. Other basic cationic amino acids (D-arginine, L-homoarginine, L-citrulline, L-lysine, and L-ornithine) evoked only small or no relaxations in both types of preparations. These observations demonstrate that L-arginine stereoselectively and specifically relaxes the rat aorta whether or not it contains the endothelium; this response depends on the duration of the prior incubation of the rings in physiological salt solution. The relaxations are impaired by inhibitors of both the formation and the action of NO, demonstrating that the endothelial cells and the vascular smooth muscle of the rat aorta possess an L-arginine - NO pathway(s) associated with relaxation.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subjectBasic Cationic Amino Acidsen_US
dc.subjectEndotheliumen_US
dc.subjectL-Arginineen_US
dc.subjectMethylene Blueen_US
dc.subjectNitro-L-Arginineen_US
dc.titleL-arginine evokes relaxations of the rat aorta in both the presence and absence of endothelial cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0025809745en_US
dc.identifier.volume17en_US
dc.identifier.issueSUPPL. 3en_US
dc.identifier.spageS10en_US
dc.identifier.epageS14en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSchini, VB=7004113565en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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