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Conference Paper: Effects of perindoprilat on endothelium-dependent relaxations and contractions in isolated blood levels

TitleEffects of perindoprilat on endothelium-dependent relaxations and contractions in isolated blood levels
Authors
Issue Date1991
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper
Citation
American Journal Of Hypertension, 1991, v. 4 n. 3 II SUPPL., p. 226S-234S How to Cite?
AbstractExperiments were designed to study the effects of perindoprilat (S 9780) on endothelium-dependent and -independent relaxations and contractions in isolated blood vessels. Rings of either canine femoral, basilar or left anterior descending coronary arteries, pulmonary veins, or thoracic aortas from normotensive and hypertensive rats were suspended in organ chambers for isometric tension measurement. Perindoprilat did not evoke endothelium-dependent or -independent relaxations of femoral arteries, basilar arteries, coronary arteries, or rat aortas. The compound did not affect the endothelium-independent relaxations induced by isoproterenol and nitroglycerin in canine femoral arteries. However, when given to rings of canine basilar and coronary arteries, increasing concentrations of perindoprilat potentiated the endothelium-dependent relaxations to bradykinin. In addition, the drug potentiated the endothelium-dependent relaxations to acetylcholine and thrombin in preparations of canine left anterior descending coronary arteries. In contrast, perindoprilat did not cause changes in tension when given in the presence of either adenosine diphosphate, serotonin, or arginine-vasopressin. The compound did not modify the endothelium-dependent contractions evoked by the calcium ionophore A23187 and acetylcholine in canine basilar arteries. It also did not alter endothelium-dependent contractions to arachidonic acid or to hypoxia in canine pulmonary veins or to acetylcholine in the aorta of the spontaneously hypertensive rat. These experiments suggest that perindoprilat (a) does not release endothelium-derived relaxing factor(s) from the endothelial cells, (b) does not interfere with the ability of the endothelium to release endothelium-derived relaxing factor(s), (c) may affect the endothelium-dependent responses to bradykinin by direct interaction with converting enzyme, (d) does not affect endothelium-dependent relaxations induced by acetylcholine and thrombin by an unknown mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/173486
ISSN
2015 Impact Factor: 3.182
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKerth, PAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:32:19Z-
dc.date.available2012-10-30T06:32:19Z-
dc.date.issued1991en_US
dc.identifier.citationAmerican Journal Of Hypertension, 1991, v. 4 n. 3 II SUPPL., p. 226S-234Sen_US
dc.identifier.issn0895-7061en_US
dc.identifier.urihttp://hdl.handle.net/10722/173486-
dc.description.abstractExperiments were designed to study the effects of perindoprilat (S 9780) on endothelium-dependent and -independent relaxations and contractions in isolated blood vessels. Rings of either canine femoral, basilar or left anterior descending coronary arteries, pulmonary veins, or thoracic aortas from normotensive and hypertensive rats were suspended in organ chambers for isometric tension measurement. Perindoprilat did not evoke endothelium-dependent or -independent relaxations of femoral arteries, basilar arteries, coronary arteries, or rat aortas. The compound did not affect the endothelium-independent relaxations induced by isoproterenol and nitroglycerin in canine femoral arteries. However, when given to rings of canine basilar and coronary arteries, increasing concentrations of perindoprilat potentiated the endothelium-dependent relaxations to bradykinin. In addition, the drug potentiated the endothelium-dependent relaxations to acetylcholine and thrombin in preparations of canine left anterior descending coronary arteries. In contrast, perindoprilat did not cause changes in tension when given in the presence of either adenosine diphosphate, serotonin, or arginine-vasopressin. The compound did not modify the endothelium-dependent contractions evoked by the calcium ionophore A23187 and acetylcholine in canine basilar arteries. It also did not alter endothelium-dependent contractions to arachidonic acid or to hypoxia in canine pulmonary veins or to acetylcholine in the aorta of the spontaneously hypertensive rat. These experiments suggest that perindoprilat (a) does not release endothelium-derived relaxing factor(s) from the endothelial cells, (b) does not interfere with the ability of the endothelium to release endothelium-derived relaxing factor(s), (c) may affect the endothelium-dependent responses to bradykinin by direct interaction with converting enzyme, (d) does not affect endothelium-dependent relaxations induced by acetylcholine and thrombin by an unknown mechanism.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyperen_US
dc.relation.ispartofAmerican Journal of Hypertensionen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Drug Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshThrombin - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleEffects of perindoprilat on endothelium-dependent relaxations and contractions in isolated blood levelsen_US
dc.typeConference_Paperen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2043312-
dc.identifier.scopuseid_2-s2.0-0025759985en_US
dc.identifier.volume4en_US
dc.identifier.issue3 II SUPPL.en_US
dc.identifier.spage226Sen_US
dc.identifier.epage234Sen_US
dc.identifier.isiWOS:A1991FD09600005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKerth, PA=55283362700en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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